| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Prolonged physical inactivity induces insulin resistance in skeletal muscles. In the present study, we examined the mechanisms of the inactivity-induced development of muscle insulin resistance by using rat unilateral hindlimb immobilization model. We found evidence suggesting that inactivity-induced muscle insulin resistance is related to reduced AS160 phosphorylation and enhanced activation of the proinflammatory/stress pathways, i.e. JNK and/or p38 MAPK pathway. In addition, our results showed that inactivity-induced muscle insulin resistance is not due to the reduced mechanical stress. Moreover, in the present study, mRNA expression of thioredoxin-interacting protein (TXNIP) that is known to be associated with insulin resistance was increased in immobilized inactive muscle. It may suggest the possibility that increased expression of TXNIP is involved in inactivity-induced muscle insulin resistance.
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