The mechanism by which physical inactivity induces insulin resistance in skeletal muscle
| Project/Area Number |
25350908
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | Fukuoka University (2015)
Niigata University of Health and Welfare (2013-2014) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAWAMOTO Emi 長岡工業高等専門学校, 准教授 (40634514)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 骨格筋 / 糖取り込み / 不活動 / ストレッチ / インスリン抵抗性 / JNK / p38 MAPK / TXNIP / ギブス固定 / CXCL1 / CXCL2 / ラット / IKK / AS160 / TBC1D1 |
|---|
| Outline of Final Research Achievements |
Prolonged physical inactivity induces insulin resistance in skeletal muscles. In the present study, we examined the mechanisms of the inactivity-induced development of muscle insulin resistance by using rat unilateral hindlimb immobilization model. We found evidence suggesting that inactivity-induced muscle insulin resistance is related to reduced AS160 phosphorylation and enhanced activation of the proinflammatory/stress pathways, i.e. JNK and/or p38 MAPK pathway. In addition, our results showed that inactivity-induced muscle insulin resistance is not due to the reduced mechanical stress. Moreover, in the present study, mRNA expression of thioredoxin-interacting protein (TXNIP) that is known to be associated with insulin resistance was increased in immobilized inactive muscle. It may suggest the possibility that increased expression of TXNIP is involved in inactivity-induced muscle insulin resistance.
|
Report
(4 results)
Research Products
(7 results)
