Impact of regular physical activity on prognosis after acute myocardial infarction

• Project/Area Number: 25350910
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kwansei Gakuin University
• Principal Investigator: SATO Hiroshi 関西学院大学, 人間福祉学部, 教授 (10294092)
• Co-Investigator(Kenkyū-buntansha): SAKATA Yasuhiko 東北大学, 大学院医学系研究科, 准教授 (90379206)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 心筋梗塞 / 運動習慣 / 運動能力 / 予後 / 冠危険因子 / 生活習慣

Outline of Final Research Achievements

Impacts of regular physical activity on prognosis are examined in large scale, real-world settings because varieties of confounding factors could influence the favorable effect of exercise seen in small clinical studies. Regular physical activity at 3-month after MI were seen 1180 patients (22.3%, total n=5170). Cumulative mortality at 5-year after MI was 3.5%, which was lower than that in the patients without regular physical activity (3990 patients, 7.9% log-rank p<0.001). However. the difference was not statistically significant in the multivariate analysis. Mortality at 5-year after MI was highest in the patients’ activity changed from active to inactive after MI and was lowest in those changed from inactive to active. Mortality at 5-year after MI was highest in lowest quartile of maximum physical capacity. We conclude that regular physical activity apparently related to better prognosis after AMI, but was not an independent predictor for 5-year mortality.

Research Products

• [Journal Article] Clinical Impact of Ventricular Tachycardia and/or Fibrillation during the Acute Phase of Acute Myocardial Infarction on In-Hospital and 5-Year Mortalities in the Percutaneous Coronary Intervention Era (2016)
  • Author(s): Masuda M, Nakatani D, Hikoso S, Suna S, Usami M, Matsumoto S, Kitamura T, Minamiguchi H, Okuyama Y, Uematsu M, Yamada T, Iwakura K, Hamasaki T, Sakata Y, Sato H, Nanto S, Hori M, Komuro I, Sakata Y
  • Journal Title: Circulation Journal Volume: unfixed
  • Peer Reviewed
• [Journal Article] Impact of coronary collaterals on in-hospital and 5-year mortality after ST-elevation myocardial infarction in the contemporary percutaneous coronary intervention era: a prospective observational study (2016)
  • Author(s): Sakata Y, Hara M Nakatani D, Suna S, Nishino M, Sato H, Nanto S, Hori M, Komuro Y
  • Journal Title: ＢＭＪ Ｏｐｅｎ Volume: unfixed
  • NAID: 120006955488
  • Peer Reviewed
• [Journal Article] Subclinical elevation of high-sensitive troponin T levels at the convalescent stage is associated with increased 5-year mortality after ST-elevation myocardial infarction (2016)
  • Author(s): Hara M, Sakata Y, Nakatani D, Suna S, Nishino M, Sato H, Kitamura T, Nanto S, Hamasaki T, Hori M, Komuro I; OACIS Investigators
  • Journal Title: Ｊ Ｃａｒｄｉｏｌ Volume: 67 Issue: 4 Pages: 314-20
  • DOI: 10.1016/j.jjcc.2015.08.021
  • Peer Reviewed
• [Journal Article] Systematic review and individual patient data meta-analysis of sex differences in depression and prognosis in persons with myocardial infarction: A MINDMAPS study (2015)
  • Author(s): Doyle, F., McGee, H., Conroy, R., Conradi, H.J., Meijer, A., Steeds, R., Sato, H., Stewart, D.E., Parakh, K., Carney, R., Freedland, K., Anselmino, M., Pelletier, R., Bos, E.H., De Jonge, P
  • Journal Title: Psychosomatic Medicine Volume: 77 Issue: 4 Pages: 419-428
  • DOI: 10.1097/psy.0000000000000174
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 C risk allele in the contemporary percutaneous coronary intervention era: a prospective observational study. (2014)
  • Author(s): Hara M, Sakata Y, Nakatani D, Suna S, Usami M, Matsumoto S, Ozaki K, Nishino M, Sato H, Kitamura T, Nanto S, Hamasaki T, Tanaka T, Hori M, Komuro I; OACIS Investigators
  • Journal Title: BMJ Open Volume: 4 Issue: 8 Pages: e005438-e005438
  • DOI: 10.1136/bmjopen-2014-005438
  • NAID: 120006955477
  • Peer Reviewed / Open Access
• [Journal Article] Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction: a prospective observational study in Japan (2014)
  • Author(s): Edahiro R, Sakata Y, Nakatani D, Suna S, Usami M, Matsumoto S, Hara M, Kitamura T, Sato H, Yamashita S, Nanto S, Hikoso S, Sakata Y, Hori M, Hamasaki T, Komuro I; OACIS Investigators.
  • Journal Title: BMJ Open. Volume: 4 Issue: 6 Pages: e005067-e005067
  • DOI: 10.1136/bmjopen-2014-005067
  • NAID: 120006955476
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of 5-year survival after acute myocardial infarction using angiotensin-converting enzyme inhibitor versus angiotensin II receptor blocker (2014)
  • Author(s): Hara M, Sakata Y, Nakatani D, Suna S, Usami M, Matsumoto S, Sugitani T, Nishino M, Sato H, Kitamura T, Nanto S, Hamasaki T, Hori M, Komuro I; OACIS Investigators.
  • Journal Title: Am J Cariolol Volume: 114 Issue: 1 Pages: 1-8
  • DOI: 10.1016/j.amjcard.2014.03.055
  • Peer Reviewed
• [Journal Article] Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction: a report from the Osaka Acute Coronary Insufficiency Study. (2014)
  • Author(s): Hara M, Sakata Y, Nakatani D, Suna S, Usami M, Matsumoto S, Sugitani T, Ozaki K, Nishino M, Sato H, Kitamura T, Nanto S, Hamasaki T, Tanaka T, Hori M, Komuro I; OACIS Investigators.
  • Journal Title: Int Heart J Volume: 55 Pages: 190-196
  • Peer Reviewed / Open Access
• [Journal Article] Clinical impact of acute hyperglycemia on development of diabetes mellitus in non-diabetic patients with acute myocardial infarction (2014)
  • Author(s): Usami M, Sakata Y, Nakatani D, Suna S, Matsumoto S, Hara M, Kitamura T, Ueda Y, Iwakura K, Sato H, Hamasaki T, Nanto S, Hori M, Komuro I.
  • Journal Title: J Cardiol Volume: 63 Issue: 4 Pages: 274-280
  • DOI: 10.1016/j.jjcc.2013.08.012
  • Peer Reviewed / Open Access
• [Journal Article] Living alone and risk of cardiovascular events following discharge after acute myocardial infarction in Japan (2013)
  • Author(s): Kitamura T, Sakata Y, Nakatani D, Suna S, Usami M, Matsumoto S, Hara M, Hamasaki T, Nanto S, Sato H, Hori M, Iso H, Komuro I.
  • Journal Title: J Cardiol Volume: 62 Issue: 4 Pages: 257-262
  • DOI: 10.1016/j.jjcc.2013.04.009
  • Peer Reviewed
• [Journal Article] Decreased Mortality Associated with Statin Treatment in Patients with Acute Myocardial Infarction and Lymphotoxin-&#61537; C804A Polymorphism. (2013)
  • Author(s): Suna Shinichiro
  • Journal Title: Atherosclerosis Volume: 227 Issue: 2 Pages: 373-379
  • DOI: 10.1016/j.atherosclerosis.2013.01.020
  • Peer Reviewed
• [Journal Article] Adjusted prognostic association of post-myocardial infarction depression with mortality and cardiovascular events: an individual patient data meta-analysis. (2013)
  • Author(s): Anna Meijer、Henk Jan Conradi, Elske Bos, Matteo Anselmino, Robert Carney, Johan Denollet, Frank Doyle, Kenneth Freedland, Sherry Grace, Seyed Hamzeh Hosseini, Deirdre Lane, Louise Pilote, Kapil Parakh, Chiara Rafanelli, Hiroshi Sato, Richard Steeds, Catharina Welin , Peter De Jonge
  • Journal Title: British Journal of Psychiatry Volume: 203 Issue: 2 Pages: 90-102
  • DOI: 10.1192/bjp.bp.112.111195
  • Peer Reviewed
• [Journal Article] Elevated serum heart-type fatty acid-binding protein in the convalescent stage predicts long-term outcome in patients surviving acute myocardial infarction (2013)
  • Author(s): Matsumoto S, Nakatani D, Sakata Y, Suna S, Shimizu M, Usami M, Hara M, Sumitsuji S, Nanto S, Sasaki T, Hamasaki T, Sato H, Hori M, Komuro I; Osaka Acute Coronary Insufficiency Study (OACIS) Group.
  • Journal Title: Circ J Volume: 77 Pages: 1026-1032
  • NAID: 10031139007
  • Peer Reviewed
• [Presentation] Impact of Regular Physical Activity on Prognosis after Myocardial Infarction: the OACIS Study (2016)
  • Author(s): Usami M, Sakata Y, Nakatani D, Mizuno H, Suna S, Matsumoto S, Shimizu M, Sato H.
  • Organizer: Epidemiology and Preventuin and Lifestyle and Cardiometabolic Health 2016 Scientific Sessions
  • Place of Presentation: Pheonix, Arizona ＵＳＡ
  • Year and Date: 2016-03-01
  • Int'l Joint Research
• [Presentation] Challenges of the Osaka Acute Coronary Insufficiency Study for the Publicity and Continuity (2014)
  • Author(s): Shinichiro Suna, Yasuhiko Sakata, Daisaku Nakatani, Masaya Usami, Sen Matsumoto, Masahiko Hara, Masami Nishino, Hiroshi Sato, Masatsugu Hori, Shinsuke Nanto, Issei Komuro, on behalf of the OACIS investigators
  • Organizer: 第76回日本循環器学会総会・学術集会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] Subclinical Elevation of High Sensitive Troponin T Levels at the Convalescent Stage Is Predictive for 5-Year Mortality After ST-Elevation Myocardial Infarction. (2014)
  • Author(s): Masahiko Hara, Yasuhiko Sakata, Daisaku Nakatani, Shinichiro Suna, Masaya Usami, Sen Matsumoto, Toshifumi Sugitani, Masami Nishino, Hiroshi Sato, Tetsuhisa Kitamura, Shungo Hikoso, Yasushi Sakata, Shinsuke Nanto, Toshimitsu Hamasaki, Masatsugu Hori, Issei Komuro,on behalf of the OACIS Investigators.
  • Organizer: American College of Cardiology scientific Session 2014
  • Place of Presentation: Washington D.C., USA
• [Presentation] 急性心筋梗塞患者における退院後遠隔期の糖尿病新規発症率とその危険因子 (2013)
  • Author(s): 宇佐美雅也、坂田泰彦、中谷大作、 砂真一郎、松本 専、原 正彦、北村哲久、佐藤 洋、南都伸介、堀 正二、小室一成
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: ホテル熊本日航
• [Presentation] 心筋梗塞症例における血圧・脂質・血糖と予後との関係 (2013)
  • Author(s): 松本 専、坂田泰彦、中谷大作、 砂真一郎、宇佐美雅也、原 正彦、北村哲久、佐々木達哉、佐藤 洋、南都伸介、堀 正二、小室一成
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: ホテル熊本日航
• [Presentation] Superior Long-term Prognostic Impact of Angiotensin Converting Enzyme Inhibitors to Angiotensin II Receptor Blockers After ST-Elevation Myocardial Infarction. (2013)
  • Author(s): Masahiko Hara, Yasuhiko Sakata, Daisaku Nakatani, Shinichiro Suna, Masaya Usami, Sen Matsumoto, Toshifumi Sugitani, Masami Nishino, Hiroshi Sato, Tetsuhisa Kitamura, Shinsuke Nanto, Toshimitsu Hamasaki, Masatsugu Hori, Issei Komuro,on behalf of the OACIS Investigators.
  • Organizer: American Heart Association scientific Session 2013
  • Place of Presentation: Dallas, USA
• [Book] ファーマナビゲーター抗凝固療法編 Chapter3 抗血小板薬・抗凝固薬のエビデンス 「抗血小板薬」 (2015)
  • Author(s): 佐藤 洋 (分担執筆)
  • Total Pages: 415
  • Publisher: メディカルビュー社