| Project/Area Number |
25350911
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Noriko 兵庫医科大学, 医学部, 准教授 (10368532)
SUZUKI Keiichiro 兵庫医科大学, 医学部, 教授 (70221322)
EGUCHI Hironobu 兵庫医科大学, 医学部, 講師 (60351798)
YOSHIHARA Daisaku 兵庫医科大学, 医学部, 助教 (00567266)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ChREBP / 酸化ストレス / 糖尿病 / 肥満 / メタボリックシンドローム / Cu, Zn-SOD / 転写因子 / 生活習慣病 / グルコース / 糖代謝 |
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| Outline of Final Research Achievements |
Carbohydrate Response Element Binding protein (ChREBP) regulates glucose and lipid metabolism via regulating glycolytic, gluconeogenic, and lipogenic gene expression. The transcriptional activation of ChREBP is regulated by concentration of glucose, however details of the mechanism for this activation remains unclear. In this study, we observed the effect of oxidative stress on the transcriptional activation of ChREBP.
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