Urinary adiponectin as an early diabetic nephropathy index
Project/Area Number |
25350912
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied health science
|
Research Institution | Tokushima Bunri University |
Principal Investigator |
Hashida Seiichi 徳島文理大学, 大学共同利用機関等の部局等, 教授 (10156268)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 糖尿病 / 腎症 / アディポネクチン / バイオマーカー / 免疫測定法 / 尿 |
Outline of Final Research Achievements |
With the aim of using urinary adiponectin (AN) as an index for early diabetic nephropathy, we developed an ultra-sensitive assay for AN. Measurements of blood and urinary concentrations of AN in patients with diabetes, obese subjects without diabetes, and healthy subjects revealed that urinary concentrations of AN did not reflect AN levels in blood, unlike leptin, resistin, or insulin. On the other hand, urinary AN correlated strongly with urinary albumin. Notably, urinary AN levels were high in some subjects in whom microalbuminuria was not detectable. Furthermore, low-molecular-weight AN (trimers) accounted for most AN in the urine, whereas middle- or high-molecular-weight AN predominated in blood. In subjects with low estimated glomerular filtration rate (eGFR), the urinary/blood AN ratio was ten times higher than that of individuals with eGFR within normal range. In conclusion, urinary AN may offer a useful new index of early diabetic nephropathy.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Endoplasmic reticulum stress induced by tunicamycin increases resistin mRNA through the PERK-ATF4-CHOP pathway in THP-1 human monocytes.2016
Author(s)
Hamada, Junpei, Onuma, Hiroshi, Ochi, Fumihiro, Hirai, Hiroki, Takemoto, Koji, Miyoshi, Akiko, Matsushita, Manami, Kadota, Yuko, Ohashi, Jun, Kawamura, Ryoichi, Takata, Yasunori, Nishida, Wataru, Hashida, Seiichi, Ishii, Eiichi, Osawa, Haruhiko.
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Journal Title
Journal of Diabetes Investigation
Volume: 7
Issue: 3
Pages: 312-323
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Immunoreactive insulin in diabetes mellitus patient sera detected by ultrasensitive ELISA with thio-NAD cycling2015
Author(s)
Ito E, Kaneda M, Kodama H, Morikawa M, Tai M, Aoki K, Watabe S, Nakaishi K, Hashida S, Tada S, Kuroda N, Imachi H, Murao K, Yamashita M, Yoshimura T, Miura T
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Journal Title
Biotechniques
Volume: 59
Issue: 6
Pages: 361-367
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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