Exercise improves the oxidative stress and the anti-atherogenic function of HDL in metabolic syndrome.

• Project/Area Number: 25350916
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Louis Pasteur Center for Medical Research
• Principal Investigator: KAWAI YUKARI 公益財団法人ルイ・パストゥール医学研究センター, その他部局等, 研究員 (80530253)
• Co-Investigator(Kenkyū-buntansha): TAKANAMI Yoshikazu 大妻女子大学, 家政学部, 教授 (40206777) ; TANIMURA Yuko 愛知東邦大学, 人間学部, 助教 (90551458)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: HDL機能 / メタボリックシンドローム / 運動 / 酸化ストレス / 慢性炎症 / HDL

Outline of Final Research Achievements

This study was aimed to elucidate whether contributes to the movement preventing atherosclerosis in terms of functional HDL improvement in the metabolic syndrome. Exercise training was significantly improve the diagnostic criteria of metabolic syndrome and inflammation and oxidative stress markers. Furthermore, HDL function was correlated with the levels of oxidized LDL and adiponectin. These findings suggest that the effect of exercise on metabolic syndrome to convert the dysfunctional HDL into functional HDL by improving inflammation and oxidative stress. Exercise can become effective means to improve the anti-atherogenic function of HDL.

Research Products

• [Presentation] メタボリックシンドロームに対する運動療法が動脈硬化危険因子に及ぼす影響 (2015)
  • Author(s): 高波嘉一，川合ゆかり，青井渉，谷村祐子，市川寛，木村穣，吉川敏一
  • Organizer: 第15回日本抗加齢医学会総会
  • Place of Presentation: 福岡市
  • Year and Date: 2015-05-29
• [Presentation] 運動療法による脂質代謝改善効果 －酸化ストレスの影響をふくめて－ (2013)
  • Author(s): 高波嘉一，川合ゆかり，青井渉，谷村祐子，市川寛，木村穣，吉川敏一
  • Organizer: 第68回日本体力医学会大会
  • Place of Presentation: 東京