| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Diversity-enhanced extracts are prepared from chemical reactions that remodel molecular scaffolds directly on extracts of natural resources. The subsequent isolation of each compound produced from such reactions affords a diverse natural product-like library. Although there have been several reports on similar methods that chemically convert natural extracts, diversity-enhanced extracts represents an unprecedented approach in terms of applying reactions to form new carbon-carbon bonds and modify molecular skeletons.
We applied this method of diversification on the medicinal plant, Curcuma zedoaria. Epoxidation and subsequent ring-opening reactions of epoxides were used to modify molecular skeletons. As a result, new and diverse sesquitepene-like compounds with some containing new molecular skeletons. Therefore, this method of diversification was efficient for producing chemically-diverse natural products.
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