Development of a comprehensive synthetic strategy and study of biological activity of yuzurimine alkaloids
| Project/Area Number |
25350960
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Okayama University (2014-2015)
University of Tsukuba (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ユズリミン類 / 分子内Wittig反応 / Sm-mediated cyclization / Staudinger反応 / aza-Wittig反応 / 天然物化学 / 全合成 / 有機合成化学 / 構造活性相関 / アセチルコリンエステラーゼ阻害活性 |
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| Outline of Final Research Achievements |
Synthetic study of all the yuzurimine-type alkaloids was investigated. We achieved the construction of the [6-7-5-5] tetracyclic core of all the carbocyclic frameworks of yuzurimine-type alkaloids by using a unique in situ intramolecular Wittig reaction and samarium-mediated cyclization as key steps. Furthermore, we designed and prepared the tricyclic iminium compound as a common intermediate of heterocyclic portion of all the yuzurimine-type alkaloids, featuring the Staudinger reaction-aza-Wittig reaction.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] The γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle.2015
Author(s)
Chinen T, Liu P, Shioda S, Pagel J, Cerikan B, Lin TC, Gruss O, Hayashi Y, Takeno H, Shima T, Okada Y, Hayakawa I, Hayashi Y, Kigoshi H, Usui T, Schiebel E
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Journal Title
Nature Communications
Volume: 6
Issue: 1
Pages: 8722-8722
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Glaziovianin A Prevents Endosome Maturation via Inhibiting Microtubule Dynamics.2013
Author(s)
Chinen T, Kazami S, Nagumo Y, Hayakawa I, Ikedo A, Takagi M, Yokosuka A, Imamoto N, Mimaki Y, Kigoshi H, Osada H, Usui T.
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Journal Title
ACS Chemical Biology
Volume: (In press)
Issue: 5
Pages: 884-889
DOI
Related Report
Peer Reviewed
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[Patent(Industrial Property Rights)] 微小管重合阻害剤2014
Inventor(s)
臼井健郎・木越英夫・早川一郎・知念拓実・塩田秀也
Industrial Property Rights Holder
臼井健郎・木越英夫・早川一郎・知念拓実・塩田秀也
Industrial Property Rights Type
特許
Industrial Property Number
2014-267073
Filing Date
2014-12-29
Related Report
