| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Synthetic study of all the yuzurimine-type alkaloids was investigated. We achieved the construction of the [6-7-5-5] tetracyclic core of all the carbocyclic frameworks of yuzurimine-type alkaloids by using a unique in situ intramolecular Wittig reaction and samarium-mediated cyclization as key steps. Furthermore, we designed and prepared the tricyclic iminium compound as a common intermediate of heterocyclic portion of all the yuzurimine-type alkaloids, featuring the Staudinger reaction-aza-Wittig reaction.
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