Production of new macrolide based on ribosome engineering
| Project/Area Number |
25350964
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Shizuoka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | マクロライド / 抗菌活性 / 放線菌 / 抗生物質 / 育種 / リボゾーム工学 |
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| Outline of Final Research Achievements |
A new 16-membered macrolide named makinolide B was isolated from Streptomyces sp. MK-19. The structure of makinolide B was determined on the basis of 2D NMR experiments including DQF-COSY, TOCSY, HSQC, and HMBC methods. As a result of paper disk diffusion method, makinolide B showed weak antibacterial activity against Staphylococcus aureus.
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Report
(4 results)
Research Products
(11 results)
