| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
Search for marine natural products capable of arresting the embryonic development of starfish at the specific stage led to discovery of new specific inhibitors of cellular functions, such as polyacetylene compounds，halogenated sesquiterpenes, macrocyclic diterpenoids which have been isolated from marine sponges, Egyptian sea hare, and Red Sea coral, respectively. The structures were elucidated on the basis of spectroscopic analyses and the absolute configuration was confirmed by X-ray analysis. We have evaluated the effects of the new compounds on echinoderm embryogenesis and human cancer cell lines. Several compounds exhibited cytotoxic activity in vitro against several human cancer cells.
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