Cellular function regulating substances that inhibit echinoderm embryogenesis
| Project/Area Number |
25350965
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
OHTA Shinji 広島大学, 生物圏科学研究科, 教授 (60185270)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 生理活性物質 / 海綿 / 軟体サンゴ / 棘皮動物 / 胚発生 / 海洋生物 / 軟体動物 |
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| Outline of Final Research Achievements |
Search for marine natural products capable of arresting the embryonic development of starfish at the specific stage led to discovery of new specific inhibitors of cellular functions, such as polyacetylene compounds，halogenated sesquiterpenes, macrocyclic diterpenoids which have been isolated from marine sponges, Egyptian sea hare, and Red Sea coral, respectively. The structures were elucidated on the basis of spectroscopic analyses and the absolute configuration was confirmed by X-ray analysis. We have evaluated the effects of the new compounds on echinoderm embryogenesis and human cancer cell lines. Several compounds exhibited cytotoxic activity in vitro against several human cancer cells.
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Report
(5 results)
Research Products
(21 results)
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[Journal Article] Petroacetylene, a new polyacetylene from the marine sponge Petrosia solida that inhibits blastulation of starfish embryos.2013
Author(s)
Ohta, S., Ogawa, T., Ohta, E., Ikeuchi, T., Kamemura, K., and Ikegami, S.
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Journal Title
Natural Product Research
Volume: 27
Issue: 20
Pages: 1842-1847
DOI
Related Report
Peer Reviewed
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