| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
In Ehime Prefecture, it is a thriving fishing industry, but not worth organisms have been discarded. In the course of our continuing search for biologically active substances from such marine organisms, we isolated bioactive compounds from marine sponges, which was collected at the Sada Cape.
An MS-guided purification of this extract revealed novel bromopyrrole alkaloids and peptide. The planar structures of these compounds ere clarified on the basis of NMR spectroscopic and mass spectrometric data. The stereochemistry of those compounds were suggested by NOE and CD experiments. Such chemicals are considered symbiotic microorganisms have produced. Therefore, separation and identification of symbiotic-microorganisms from marine sponge have been done. Further cultivation of symbiotic microorganisms are under way in our laboratory.
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