Biofilm formation mechanism by intercellular signaling molecule of environmental pathogen
| Project/Area Number |
25350968
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIUCHI Yuji 大阪市立大学, 大学院医学研究科, 学外研究員 (30132814)
MATSUMOTO Sohkichi 新潟大学, 大学院医歯学総合研究科, 教授 (30244073)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 非結核性抗酸菌 / バイオフィルム / トリ型結核菌 / グリコペプチドリピド / 低酸素 / トレハロースジマイコレート / 細胞間情報伝達物質 / Mycobacterium avium |
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| Outline of Final Research Achievements |
The incidence of pulmonary Mycobacterium avium complex (MAC) disease is increasing in Japan. This disease is generally developed by inhalation of MAC organisms occurring in the environment. MAC forms biofilm in the environment and hosts, and the biofilm can function to shelter MAC itself. Thus, the formed biofilm makes it difficult to eliminate MAC organisms from the infection sources and hosts. However, the biology and the regulatory mechanism of biofilm formation of MAC still remain unknown. The aim of this research is to elucidate these pending issues with the biofilm formation of MAC. We were able to demonstrate that the ambient hypoxia and eutrophic conditions promote MAC biofilm formation, and that glycolipids existing on the envelope of MAC, such as glycopeptidolipid, trehalose dimycolate, and trehalose monomycolate, are greatly involved in the formation of biofilm. Based on these findings, we are trying to find out measures that can effectively disinfect MAC organisms.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] A new screen for tuberculosis drug candidates utilizing a luciferase-expressing recombinant Mycobacterium bovis Bacillus Calmette-Guerin2015
Author(s)
Ozeki Y, Igarashi M, Doe M, Tamaru A, Kinoshita N, Ogura Y, Iwamoto T, Sawa R, Umekita M, Enany S, Nishiuchi Y, Osada-Oka M, Hayashi T, Niki M, Tateishi Y, Hatano M, Matsumoto S.
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Journal Title
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] ntra-subspecies sequence variability of the MACPPE12 gene in Mycobacterium avium subsp. Hominissuis2014
Author(s)
Iwamoto T, Arikawa K, Nakajima C, Nakanishi N, Nishiuchi Y, Yoshida S, Tamaru A,Tamura Y, Hoshino Y, Yoo H, Park YK, Saito H, Suzuki Y
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Journal Title
Infect. Genet. Evolu.
Volume: 21
Pages: 476-483
DOI
Related Report
Peer Reviewed / Open Access
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