| Project/Area Number |
25350976
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | University of Toyama |
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Principal Investigator |
CHIBA Junya 富山大学, 大学院医学薬学研究部(薬学), 助教 (50436789)
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| Co-Investigator(Renkei-kenkyūsha) |
HATANAKA Yasumaru 富山大学, 事務局, 理事・副学長 (30111181)
TOMOHIRO Takenori 富山大学, 大学院医学薬学研究部(薬学), 准教授 (70357581)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 医薬品探索 / シアル酸誘導体 / クリックケミストリー / アシルスルホンアミド / スルホニルアミジン / ノイラミニダーゼ / 阻害剤 / 抗インフルエンザ / シアル酸 / スルホクリック / チオアミドクリック / アニオン / スルホクリック反応 / スルホニルアジド / チオアミド |
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| Outline of Final Research Achievements |
In this study, we developed novel candidates of anti-flu medicine. We originally designed them based on the plus and minus charge in the zanamivir and derivatized them effictiently by means of click chemistry. The candidate inhibitors showed high inhibitory ability to neuraminidase comparable to that of zanamivir. In addition, they also exhibited high affinity to the mutant neuraminidase with oseltamivir resistant. We applied 3 patents, got 1 patent, had 17 presentations, reported 3 original articles, and published 1 book in regard to the results in this study.
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