| Project/Area Number |
25350981
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Kawatani Makoto 国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 (50391925)
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| Research Collaborator |
OKUMURA Hideo 公益財団法人高輝度光科学研究センター, タンパク質結晶解析推進室, 研究員 (90377903)
SHIMIZU Takeshi 国立研究開発法人理化学研究所, 環境資源科学研究センター, 嘱託職員
HIRANUMA Sayoko 国立研究開発法人理化学研究所, 環境資源科学研究センター, 嘱託職員
WIERZBA Konstanty 国立研究開発法人理化学研究所, 環境資源科学研究センター, 嘱託職員
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | がん / 抗がん剤 |
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| Outline of Final Research Achievements |
The purpose of this study is to develop novel anti-cancer agents targeting de novo pyrimidine biosynthetic pathway based on our recently-discovered DI-01 compound. DI-01 strongly inhibited cell proliferation in a wide variety of human cancer cell lines, and showed a marked synergistic effect when used with 5-fluorouracil (5-FU). Although DI-01 was poorly-soluble and metabolically unstable, we successfully developed DI-148 with a good pharmacokinetic profile by a series of structure optimization.
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