Development of novel anti-cancer agents targeting de novo pyrimidine biosynthetic pathway
| Project/Area Number |
25350981
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Kawatani Makoto 国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 (50391925)
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| Research Collaborator |
OKUMURA Hideo 公益財団法人高輝度光科学研究センター, タンパク質結晶解析推進室, 研究員 (90377903)
SHIMIZU Takeshi 国立研究開発法人理化学研究所, 環境資源科学研究センター, 嘱託職員
HIRANUMA Sayoko 国立研究開発法人理化学研究所, 環境資源科学研究センター, 嘱託職員
WIERZBA Konstanty 国立研究開発法人理化学研究所, 環境資源科学研究センター, 嘱託職員
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | がん / 抗がん剤 |
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| Outline of Final Research Achievements |
The purpose of this study is to develop novel anti-cancer agents targeting de novo pyrimidine biosynthetic pathway based on our recently-discovered DI-01 compound. DI-01 strongly inhibited cell proliferation in a wide variety of human cancer cell lines, and showed a marked synergistic effect when used with 5-fluorouracil (5-FU). Although DI-01 was poorly-soluble and metabolically unstable, we successfully developed DI-148 with a good pharmacokinetic profile by a series of structure optimization.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Reveromycin A Administration Prevents Alveolar Bone Loss in Osteoprotegerin Knockout Mice with Periodontal Disease2015
Author(s)
Mizuno M, Miyazawa K, Tabuchi M, Tanaka M, Yoshizako M, Minamoto C, Torii Y, Tamaoka Y, Kawatani M, Osada H, Maeda H, Goto S
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Journal Title
Sci Rep
Volume: 5
Issue: 1
Pages: 16510-16510
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Polarization of osteoclasts on dental implant materials is similar to that observed on bone.2014
Author(s)
Nakayama T., Thirukonda G. J., Nagasawa S., Kawahara I, Udagawa N., Yagami K., Kawatani M., Osada H., Doi Y., Yoshinari N., and Takahashi N.
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Journal Title
J. Oral Biosci.
Volume: 56
Issue: 4
Pages: 136-142
DOI
Related Report
Peer Reviewed / Open Access
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