Chemical biology of retina-protective electrophilic compounds
Project/Area Number |
25350985
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Basic / Social brain science
|
Research Institution | Tokyo University of Technology (2014-2015) Iwate University (2013) |
Principal Investigator |
SATOH Takumi 東京工科大学, 応用生物学部, 教授 (10300831)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | Nrf2 / HSF-1 / Keap1 / HSP90 / Electrophile / Neuronal death / Oxidative stress / Retina / 網膜細胞 / 酸化ストレス / ストレス応答 / 抗酸化酵素群 / 熱ショックタンパク質 |
Outline of Final Research Achievements |
Keap1/Nrf2 and HSP90/HSF-1 pathways play a central role in combatting cellular oxidative damage and related endoplasmic reticulum stress. Electrophilic compounds have been shown to be activators of these transcription-mediated responses. We hypothesized that the para-hydroquinone moiety was critical for this activation because it enhanced transcription of these neuroprotective pathways to a greater degree than that of the corresponding ortho-hydroquinone isomer. This notion was based on the differential oxidation potentials of the isomers for the transformation of the hydroquinone to the active, electrophilic quinone species. Here, to further test this hypothesis, we synthesized a pair of para- and ortho-hydroquinone-based proelectrophilic compounds and measured their redox potentials using analytical cyclic voltammetry. The redox potential was then compared with functional biological activity, and the para-hydroquinones demonstrated a superior neuroprotective profile.
|
Report
(4 results)
Research Products
(15 results)
-
-
-
[Journal Article] Marine Hydroquinone Zonarol Prevents Inflammation and Apoptosis in Dextran Sulfate Sodium-Induced Mice Ulcerative Colitis2014
Author(s)
Sohsuke Yamada , Tomoyuki Koyama , Hirotsugu Noguchi, Yuki Ueda, Ryo Kitsuyama, Hiroya Shimizu, Akihide Tanimoto, Ke-Yong Wang, Aya Nawata, Toshiyuki Nakayama, Yasuyuki Sasaguri, Takumi Satoh
-
Journal Title
PloSone
Volume: 19
Issue: 11
Pages: e113509-e113509
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-