| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We established an experimental method for accurate evaluation of axonal conduction of action potentials along myelinated fibers in rat hippocampus by employing quantal-like analysis. For the methods, we measured the latency differences of action potentials and the length of myelin-forming processes which reflects internodal length, and made the histograms for their distribution. This method was useful for detection of the developmental changes of conduction velocity and the modulatory effects of neurotransmitter receptor activation on axonal conduction. These results suggest that this method can be applied for investigation of the interaction between oligodendrocyte/myelin and axon.
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