Analysis of schizophrenia pathogenesis using mouse models based on human genetics data

• Project/Area Number: 25350987
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Basic / Social brain science
• Research Institution: Kyoto University
• Principal Investigator: Sakurai Takeshi 京都大学, 医学(系)研究科(研究院), 准教授 (90615717)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 統合失調症 / マウスモデル / ヒトゲノム解析 / 認知機能 / 社会性行動 / 前頭前野

Outline of Final Research Achievements

We have characterized several behavioral paradigm focusing on cognitive functions which prefrontal cortex is responsible for by using mouse models developed based on the human genetics data of schizophrenia. Moreover, we have also characterized the developmental processes of mouse prefrontal cortex by using gene expression profiles for several different biological processes taken place during development. These results should help us to establish basis for further characterization of mouse models for schizophrenia in order to understand the pathogenesis and pathophysiology of schizophrenia.

Research Products

• [Int'l Joint Research] Johns Hopkins University(米国)
• [Journal Article] Converging models of schizophrenia - Network alterations of prefrontal cortex underlying impairments (2015)
  • Author(s): Takeshi Sakurai, Nao J. Gamo, Takatoshi Hikida, Sun-Hong Kim, Toshiya Murai, Toshifumi Tomoda, Akira Sawa
  • Journal Title: Progress in Neurobiology Volume: 134 Pages: 178-201
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Sequence of molecular events during maturation of developing mouse prefrontal cortex. (2015)
  • Author(s): Ueda S, Niwa M, Hioki H, Sohn J, Kaneko T, Sawa A, *Sakurai T.
  • Journal Title: Mol Neuropsychiatry Volume: 1 Issue: 2 Pages: 94-104
  • DOI: 10.1159/000430095
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sequence of molecular events during maturation of developing mouse prefrontal cortex (2015)
  • Author(s): Shuhei Ueda, Minae Niwa, Hiroyuki Hioki, Jaerin Sohh, Takeshi Kaneko, Akira Sawa, Takeshi Sakurai
  • Journal Title: Molecular Neuropsychiatry Volume: NA
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Analysis of Gtf2i mutant mice exhibiting abnormal social behavior (2015)
  • Author(s): Shuhei Ueda, Akira Sawa, Takeshi Sakurai
  • Organizer: Annual meeting of Society for Neuroscience
  • Place of Presentation: Chicago
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Analysis of Gtf2i mutant mice exhibiting abnormal social behaviors (2015)
  • Author(s): Shuhei Ueda, Akira Sawa, Takeshi Sakurai
  • Organizer: 日本神経科学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-28
• [Presentation] Developmental profiles of prefrontal cortex of normal and disease model mice (2015)
  • Author(s): Shuhei Ueda, Minae Niwa, Akira Sawa, Takeshi Sakurai
  • Organizer: Cold Spring Harbor Meeting, Wiring the Brain
  • Place of Presentation: Cold Spring Harbor, US
  • Year and Date: 2015-03-24 – 2015-03-28
• [Presentation] Shuhei Ueda, Minae Niwa, Hiroyuki Hioki, Jaerin Sohn, Takeshi Kaneko, Akira Sawa, Takeshi Sakurai (2015)
  • Author(s): Maturation processes of developing prefrontal cortex of normal and disease model mice
  • Organizer: 日本解剖学会総会・全国学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Prefrontal cortex as targets of developmental insults associated with developmental psychiatric disorders -mouse model analysis- (2015)
  • Author(s): Takeshi Sakurai, Shuhei Ueda, Minae Niwa, Akira Sawa
  • Organizer: 日本薬理学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-03-18 – 2015-03-20
  • Invited
• [Presentation] Comprehensive gene expression profiling associated with the prefrontal circuit maturation (2014)
  • Author(s): Shuhei Ueda, Minae Niwa, Akira Sawa, Takeshi Sakurai
  • Organizer: Annual meeting of Society for Neuroscience
  • Place of Presentation: Washington DC, US
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Comprehensive gene expression profiling associated with the prefrontal circuit maturation (2014)
  • Author(s): Shuhei Ueda, Minae Niwa, Akira Sawa, Takeshi Sakurai
  • Organizer: 日本神経科学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] 統合失調症の分子病態の理解を目的としたPTPRAノックアウトマウスおよびPTPRZトランスジェニックマウスの解析 (2014)
  • Author(s): 上田修平、澤明、櫻井武
  • Organizer: 日本統合失調症学会
  • Place of Presentation: 京都テルサ、京都
• [Presentation] Towards understanding pathogenesis of schizophrenia through analysis of PTPRA knockout mice and PTPRZ transgenic mice (2013)
  • Author(s): Takeshi Sakurai, Toshifumi Tomoda, Takatoshi Hikida, Akira Sawa
  • Organizer: World Federation of Societies of Biological Psychiatry Congress
  • Place of Presentation: 京都国際会館、京都