The analysis of cholinergic modulations of the visual responsiveness
| Project/Area Number |
25350991
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic / Social brain science
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| Research Institution | National Center of Neurology and Psychiatry (2015)
The Institute of Physical and Chemical Research (2013-2014) |
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Principal Investigator |
Sohya Kazuhiro 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第三部, 室長 (80415207)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 二光子レーザー走査型顕微鏡 / カルシウムイメージング / 大脳皮質視覚野 / 方位選択性 / in vivo / 視覚応答 / 蛍光タンパク質 / 抑制性ニューロン / 二光子励起 / GFP / 大脳皮質初期視覚野 / GABAニューロン / 覚醒脳 / ニューロンクラスター / コリン作動性ニューロン |
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| Outline of Final Research Achievements |
In this study, I revealed that the effect of awakening is mediated mainly through the activation of GABAergic neurons, which modifies the visual responses of excitatory neurons. Also I developed the new method of GABAergic neuron activity in 3D space. Then I revealed that GABAergic interneurons form clusters to make their inhibitory function.
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Report
(4 results)
Research Products
(7 results)
