Individual differences revealed by brain network analysis based on graph theory

• Project/Area Number: 25350994
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Basic / Social brain science
• Research Institution: Wakayama Medical University
• Principal Investigator: Donishi Tomohiro 和歌山県立医科大学, 医学部, 助教 (70326354)
• Co-Investigator(Kenkyū-buntansha): KANEOKE Yoshiki 和歌山県立医科大学, 医学部, 教授 (20280589)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: individual difference / sex difference / fMRI / functional network / graph theory / resting state / personality / 個性の神経基盤 / 脳内ネットワーク / 安静時脳活動 / パーソナリティ / 男女差

Outline of Final Research Achievements

We explored the neural basis of individual difference and personality by network analysis of the resting-state brain. We introduced normalized alpha-centrality to characterize the brain functional network for the first time in the field, and applied it successfully to the following: 1) Sex differences of the brain functional network. Significant sex differences were revealed at the bilateral insula, right inferior frontal gyrus, and cuneus, suggesting that these regions play an important role in the neural basis of sex differences. 2) Brain networks related to personality traits. Multiple segregated regions were found to show significant correlations with personality scores defined in Cloninger's Temperament and Character Inventory and Big-Five model. Results suggest that these regions are related to the corresponding personality traits, each of which is carved in the resting-state brain functional network.

Research Products

• [Journal Article] Use of T1-weighted/T2-weighted magnetic resonance ratio images to elucidate changes in the schizophrenic brain (2015)
  • Author(s): Iwatani J, Ishida T, Donishi T, Ukai S, Shinosaki K, Terada M, Kaneoke Y
  • Journal Title: Brain Behav Volume: 5 Issue: 10 Pages: 1-14
  • DOI: 10.1002/brb3.399
  • Peer Reviewed / Open Access
• [Presentation] 安静時脳内機能的ネットワークの男女差 (2016)
  • Author(s): 堂西倫弘、石田卓也、寺田正樹、金桶吉起
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2016-07-20
• [Presentation] 安静時脳内機能的ネットワークの男女差 (2016)
  • Author(s): 堂西倫弘、石田卓也、寺田正樹、金桶吉起
  • Organizer: 第18回日本ヒト脳機能マッピング学会
  • Place of Presentation: 京都、京都大学桂キャンパス
  • Year and Date: 2016-03-07
• [Presentation] 男と女の脳内神経回路の違い (2016)
  • Author(s): 堂西倫弘、石田卓也、寺田正樹、金桶吉起
  • Organizer: 第4回ニューロカンファレンス和歌山
  • Place of Presentation: 和歌山、和歌山県民文化会館
  • Year and Date: 2016-01-09
• [Presentation] 安静時脳活動の男女差：正規化アルファ中心性によるネットワーク構造の検討 (2015)
  • Author(s): 堂西倫弘、石田卓也、寺田正樹、金桶吉起
  • Organizer: 第108回近畿生理学談話会
  • Place of Presentation: 大阪、近畿大学
  • Year and Date: 2015-10-24
• [Presentation] 安静時機能的MRIによる脳内機能的ネットワーク構造の男女差の解明 (2015)
  • Author(s): 堂西倫弘、石田卓也、寺田正樹、金桶吉起
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸、神戸コンベンションセンター
  • Year and Date: 2015-07-28
• [Presentation] Sex difference of the brain network structure as revealed by normalized alpha-centrality (2015)
  • Author(s): Donishi T, Ishida T, Terada M, Kaneoke Y
  • Organizer: OHBM2015
  • Place of Presentation: ホノルル、ハワイコンベンションセンター
  • Year and Date: 2015-06-14
  • Int'l Joint Research
• [Presentation] パーソナリティ特性に関わる安静時脳内ネットワーク (2015)
  • Author(s): 堂西倫弘
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸市、神戸国際会議場
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Personality traits are carved in the resting-state brain networks (2014)
  • Author(s): 堂西倫弘
  • Organizer: 北米神経科学学会 Neuroscience 2014
  • Place of Presentation: 米国ワシントンDC、コンベンションセンター
  • Year and Date: 2014-11-14 – 2014-11-19
• [Presentation] パーソナリティ形成に関わる脳内ネットワーク (2014)
  • Author(s): 堂西倫弘
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜市、パシフィコ横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] パーソナリティ特性の神経相関：安静時機能的MRIを用いた検討 (2014)
  • Author(s): 堂西倫弘
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島県鹿児島市、鹿児島大学
• [Presentation] Sex difference of the human brain functional connectivity related to the second to fourth digit ratio (2013)
  • Author(s): 堂西倫弘
  • Organizer: IUPS2013, 国際生理学会議
  • Place of Presentation: 英国バーミンガム、国際会議場
• [Presentation] 安静時機能的MRIを用いた長周期脳活動とパーソナリティの関連 (2013)
  • Author(s): 堂西倫弘
  • Organizer: 第106回近畿生理学談話会
  • Place of Presentation: 奈良県橿原市、奈良県立医科大学