| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
We explored the neural substrates to regulate M1 excitability through EEG analysis and developed a new protocol for non-invasive brain stimulation. EEGs were recorded during TMS over left M1. MEPs were also recorded and EEG powers were compared between trials of higher MEP amplitudes and ones of lower amplitudes. We found that higher α and β power of C3, which was closest to TMS coil, were related to higher MEP amplitudes. The relationship was also dependent on TMS intensity. TMS intensity would influence the cortical area affected by TMS, thus higher TMS intensity would reflect the excitability of larger cortical area compared with lower TMS intensity.
Transcranial alternating current stimulation (tACS) was performed over M1 to modulate M1 excitability. It was revealed that the MEP amplitudes were modulated dependent on its frequency and also its phase. tACS would entrain cortical oscillations and modulate M1 excitability depending on its phase.
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