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Development and validation of the real-time quantification of cerebral blood flow using an arterial spin labeling MRI

Research Project

Project/Area Number 25351003
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Brain biometrics
Research InstitutionNational Institute of Information and Communications Technology

Principal Investigator

Toyoda Hiroshi  国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター脳情報通信融合研究室, 主任研究員 (10558084)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
KeywordsMRI / 脳血流量 / 動脈スピン標識法
Outline of Final Research Achievements

We have developed a novel real-time measurement technique for quantitating cerebral blood flow using an arterial spin labeling method. Compared to the BOLD signal measurement, which is commonly used as a functional MRI method, the arterial spin labeling method generally requires more measurement time to image whole brain functions. In this study, high-speed MR imaging of cerebral blood flow was conducted by applying a parallel imaging technique to the arterial spin labeling method. To parallelize the imaging, we used a simultaneous multi-slice imaging technique with multi-band excitation RF pulses. Because it is less prone to magnetic susceptibility artifacts, the proposed imaging method may be used to investigate areas in the brain that were difficult to image using conventional BOLD functional MRI techniques.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 2015 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (12 results) (of which Int'l Joint Research: 6 results,  Invited: 1 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression.2015

    • Author(s)
      Cui, Y., Toyoda, H., Sako, T., Onoe, K., Hayashinaka, E., Wada, Y., Yokoyama, C., Onoe, H., Kataoka, Y., and Watanabe, Y.
    • Journal Title

      NeuroImage

      Volume: 108 Pages: 17-22

    • DOI

      10.1016/j.neuroimage.2014.12.047

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] An optimized slice-GRAPPA reconstruction method to reduce leakage artifacts in small-animal multiband imaging2017

    • Author(s)
      Hiroshi Toyoda, Sosuke Yoshinaga, Naoya Yuzuriha, Mitsuhiro Takeda, and Hiroaki Terasawa
    • Organizer
      ISMRM 25th Annual Meeting & Exhibition for Magnetic Resonance in Medicine
    • Place of Presentation
      Hawaii Convention Center, Honolulu, USA
    • Year and Date
      2017-04-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An iterative reconstruction method for dual-band EPI in small-animal studies2016

    • Author(s)
      Hiroshi Toyoda, Naoya Yuzuriha, Sosuke Yoshinaga, and Hiroaki Terasawa
    • Organizer
      ISMRM 24th Annual Meeting & Exhibition for Magnetic Resonance in Medicine
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre, Singapore, Singapore
    • Year and Date
      2016-05-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Image-based phase correction for dual-band EPI with slice-GRAPPA using point-by-point procedures in k-space2016

    • Author(s)
      Hiroshi Toyoda, Sosuke Yoshinaga, Naoya Yuzuriha, and Hiroaki Terasawa
    • Organizer
      ISMRM 24th Annual Meeting & Exhibition for Magnetic Resonance in Medicine
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre, Singapore, Singapore
    • Year and Date
      2016-05-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel reconstruction method for multi-band EPI in animal scanners with iterative point-by-point procedures in k-space.2015

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., Kusanagi, S. and Terasawa, H.
    • Organizer
      ESMRMB 2015 32nd Annual Scientific Meeting
    • Place of Presentation
      Edinburgh, UK
    • Year and Date
      2015-10-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] A robust Nyquist ghost suppression for high-resolution echo planar imaging of small animal brains.2015

    • Author(s)
      Toyoda, H., Yuzuriha, N., Yoshinaga, S., and Terasawa, H.
    • Organizer
      21st Annual Meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2015-06-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pre-scan with half-sized phase encoding blips reducing ghost and slice leakage artifacts in dual-band EPI2015

    • Author(s)
      Toyoda, H., Yuzuriha, N., Yoshinaga, S., and Terasawa, H.
    • Organizer
      ISMRM 23th Annual Meeting & Exhibition
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2015-05-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Migraine pathophysiology studied with small-animal PET2014

    • Author(s)
      Yilong Cui, Hiroshi Toyoda, Takeo Sako, Kayo Onoe, Emi Hayashinaka, Yasuhiro Wada, Chihiro Yokoyama, Hirotaka Onoe, Yosky Kataoka, Yasuyoshi Watanabe
    • Organizer
      The First CiNet Conference New Directions in Pain Neuroscience
    • Place of Presentation
      Center for Information and Neural Networks, Osaka
    • Year and Date
      2014-12-02
    • Related Report
      2014 Research-status Report
  • [Presentation] Ghost artifact correction for multiband echo planar imaging2014

    • Author(s)
      Toyoda H
    • Organizer
      電子情報通信学会ヒューマンコミュニケーショングループ 「情報の認知と行動研究会ワークショップ2014」
    • Place of Presentation
      サントピア岡山総社、岡山県総社市
    • Year and Date
      2014-10-02
    • Related Report
      2014 Research-status Report
  • [Presentation] ラット新生仔眼窩下神経切断による第一次・二次三叉神経路に対する影響の11.7T超高磁場核磁気共鳴生体イメージング2014

    • Author(s)
      大井 康浩,乾(山本)千珠子,豊田 浩士,精山 明敏,吉岡 芳親,関 淳二
    • Organizer
      第37回日本神経科学大会Neuroscience2014
    • Place of Presentation
      パシフィコ横浜,横浜市
    • Year and Date
      2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Interleaved multi-slab 3D gradient and spin echo for arterial spin labeling2013

    • Author(s)
      Hiroshi Toyoda, Guoxian Liu, Yusuke Morito, Yasuyoshi Watanabe
    • Organizer
      ISMRM 21th Annual Meeting & Exhibition
    • Place of Presentation
      Salt Palace Convention Center, Salt Lake City,USA
    • Related Report
      2013 Research-status Report
  • [Presentation] MRIの撮像原理とRFコイル,パルス系列作成法2013

    • Author(s)
      豊田 浩士
    • Organizer
      日本生物物理学会九州支部・熊本大学イメージングセミナー
    • Place of Presentation
      熊本県熊本市,熊本大学
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] MicroPETを用いた急性および慢性疼痛モデルラットにおける疼痛認知・伝達回路の解析2013

    • Author(s)
      崔 翼龍,佐古 健生,豊田 浩士,林中 恵美,和田 康弘,渡辺 恭良,片岡 洋祐
    • Organizer
      Neuro2013
    • Place of Presentation
      京都府京都市,京都国際会議場
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 磁気共鳴イメージングシステム2016

    • Inventor(s)
      豊田 浩士
    • Industrial Property Rights Holder
      国立研究開発法人情報通信研究機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-085232
    • Filing Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 磁気共鳴イメージングシステムおよびイメージング方法2015

    • Inventor(s)
      豊田 浩士
    • Industrial Property Rights Holder
      国立研究開発法人情報通信研究機構
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-05-14
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 磁気共鳴イメージングシステム、およびイメージング方法2015

    • Inventor(s)
      豊田 浩士
    • Industrial Property Rights Holder
      国立研究開発法人情報通信研究機構
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-05-22
    • Related Report
      2015 Research-status Report

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Published: 2014-07-25   Modified: 2020-03-30  

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