| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Zebrafish are becoming popular vertebrate animal models for many biomedical investigations including perceptual and learning research. However, basic behavioral perceptual and learning characteristics, such as behavioral audiogram, behavioral Critical Flicker Fusion Frequency (CFF) and spatial contrast sensitivity function (CSF) have not been determined yet. We have developed equipment for measuring characteristics of zebrafish perception. In addition to the studies of perception, age-dependent change in learning flexibility that can be used as an index of aging of brain function has been examined using a repeated reversal learning paradigm.
Behavioral auditory threshold was lower than physiological data. Behavioral CFF of zebrafish was almost same as that obtained in humans. Spatial CSF obtained in the present experiment was lower than in goldfish. Our learning flexibility experiment revealed that brain flexibility of zebrafish drastically decreased around 420 days post hatch.
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