| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Nanocarbons such as carbon nanotubes (CNTs) and nanohorns (CNHs) have recently garnered interest in the field of nanomedicine. However, the nanocarbons are easily accumulated by reticuloendothelial system such as liver or the spleen although it is less toxic. Understanding the long-term fate, health impact, excretion, and degradation of these materials have become crucial before practical uses. In this study, we have developed a new methodology for investigation of the biodegradation of CNHs in vitro and in vivo by using an optical absorption method. By using this methodology, the biodegradation degrees of CNHs with different sizes and surface modifications have been measured. The CNH-conjugate with easy degradation property has been prepared and its degradation possibility is investigated by in vivo test.
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