Preparation of a biodegradable conjugate with carbon nanomaterial for targeted cancer therapy
| Project/Area Number |
25390024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nanomaterials chemistry
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
Zhang Minfang 国立研究開発法人産業技術総合研究所, ナノチューブ実用化研究センター, 主任研究員 (60518330)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | カーボンナノチューブ / カーボンナノホーン / 生分解 / 生体内分解 / ＤＤＳ / カーボンナノ材料 / 生分解性 / DDS / ナノホーン / ナノカーボン / ナノチューブ / 酵素 |
|---|
| Outline of Final Research Achievements |
Nanocarbons such as carbon nanotubes (CNTs) and nanohorns (CNHs) have recently garnered interest in the field of nanomedicine. However, the nanocarbons are easily accumulated by reticuloendothelial system such as liver or the spleen although it is less toxic. Understanding the long-term fate, health impact, excretion, and degradation of these materials have become crucial before practical uses. In this study, we have developed a new methodology for investigation of the biodegradation of CNHs in vitro and in vivo by using an optical absorption method. By using this methodology, the biodegradation degrees of CNHs with different sizes and surface modifications have been measured. The CNH-conjugate with easy degradation property has been prepared and its degradation possibility is investigated by in vivo test.
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Report
(5 results)
Research Products
(32 results)
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[Journal Article] "Near-Infrared Photoluminescent Carbon Nanotubes for Imaging of Brown Fat2017
Author(s)
Masako Yudasaka, Yohei Yomogida, Minfang Zhang, Takeshi Tanaka, Masako Nakahara, Norihiko Kobayashi, Yuko Okamatsu-Ogura, Ken Machida, Kazuhiko Ishihara, Kumiko Saeki, Hiromichi Kataura
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Journal Title
Scientfic Reports
Volume: 7
Issue: 1
Pages: 44760-44760
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Individualized p-Doped Carbon Nanohorns2016
Author(s)
Anastasios Stergiou, Zheng Liu, Bin Xu, Toshiro Kaneko, Christopher P. Ewels, Kazu Suenaga, Minfang Zhang, Masako Yudasaka, and Nikos Tagmatarchis
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Journal Title
Angew.Chem.Int. Ed.
Volume: 55
Issue: 35
Pages: 10468-10472
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Long-term biopersistence of tangled oxidized carbon nanotubes inside and outside macrophages in rat subcutaneous tissue2013
Author(s)
Y. Sato, A. Yokoyama, Y. Nodasaka, T. Kohgo, K. Motomiya, H. Matsumoto, E. Nakazawa, T. Numata, M. Zhang, M. Yudasaka, H. Hara, R. Araki, O. Tsukamoto, H. Saito, T. Kamino, F. Watari, K. Tohji
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Journal Title
Scientific Reports
Volume: 3
Issue: 1
Pages: 1-9
DOI
Related Report
Peer Reviewed
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