High-pressure microscopy for controlling the structure of protein filaments
| Project/Area Number |
25390037
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nanobioscience
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 高圧力 / 顕微鏡 / 微小管 / べん毛 / ナノバイオ / 分子モーター / 分子機械 / タンパク質水和 / 高圧力顕微鏡 / 水和 / べん毛繊維 / 超らせん構造 |
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| Outline of Final Research Achievements |
We have developed a high-pressure microscope that enables to observe the structure and function of protein molecules. In this research project, we have studied the conformational changes of protein filaments at high-pressure. By using this system, we were successful to change the helical structure of flagellar filaments and microtubule dynamics.
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Report
(4 results)
Research Products
(41 results)
