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Development of a quantum-enhanced biological electron microscope

Research Project

Project/Area Number 25390083
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Thin film/Surface and interfacial physical properties
Research InstitutionAkita Prefectural University

Principal Investigator

Okamoto Hiroshi  秋田県立大学, システム科学技術学部, 准教授 (70455799)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords電子顕微鏡 / 超伝導量子ビット / エンタングルメント / 電界放射
Outline of Final Research Achievements

Today's biological electron microscopy faces a significant problem: Radiation damage. Too few imaging electrons result in a noisy image, whereas too many electrons lead to destruction of the frozen biological specimen. This is the dilemma, which appears to be a fundamental barrier. We set out to solve this problem using quantum technologies. Initially we proposed to use the Cooper pair box that is a superconducting charge qubit, on an electron mirror inside a transmission electron microscope (TEM).
In the project we theoretically found that a flux-based qubit would work better and we further analyzed properties of it. Because of this finding, we had to make a major change in our plan and move away from the idea of electron mirror. Nonetheless, we tested the vacuum system as well as a pulse tube refrigerator, which will be necessary setups no matter how we will proceed in the future.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2017 2015 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (5 results) (of which Invited: 4 results) Remarks (3 results)

  • [Journal Article] Quantum interface to charged particles in a vacuum2015

    • Author(s)
      Hiroshi Okamoto
    • Journal Title

      Physical Review A

      Volume: 92 Issue: 5 Pages: 053805-053805

    • DOI

      10.1103/physreva.92.053805

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Measurement errors in entanglement-assisted electron microscopy2015

    • Author(s)
      Hiroshi Okamoto
    • Journal Title

      Phys. Rev. A

      Volume: 89 Issue: 6 Pages: 0638281-17

    • DOI

      10.1103/physreva.89.063828

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Entanglement-assisted electron microscopy based on a flux qubit2014

    • Author(s)
      Hiroshi Okamoto and Yukinori Nagatani
    • Journal Title

      Applied Physics Letters

      Volume: 104 Issue: 6 Pages: 62604-62604

    • DOI

      10.1063/1.4865244

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 超伝導量子ビットと荷電粒子光学2017

    • Author(s)
      岡本 洋
    • Organizer
      第六回情報ナノシステム研究会 (H28年度)、共催 日本機械学会マイクロエネルギー研究会
    • Place of Presentation
      仙台国際ホテル
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Quantum enhanced electron microscopy: Possibilities and limitations2015

    • Author(s)
      岡本 洋
    • Organizer
      情報ナノシステム研究会
    • Place of Presentation
      笹谷温泉一の湯
    • Year and Date
      2015-03-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] QEM with superconducting qubits: possibilities and limitations2015

    • Author(s)
      Hiroshi Okamoto
    • Organizer
      Biannual Meeting for Quantum Electron Microscopy
    • Place of Presentation
      Massachusetts Institute of Technology
    • Year and Date
      2015-03-02 – 2015-03-03
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 量子もつれ:セキュリティから高精度計測まで2014

    • Author(s)
      岡本 洋
    • Organizer
      液晶フォトニクス・光デバイスフォーラム研究会
    • Place of Presentation
      カレッジプラザ(秋田市)
    • Year and Date
      2014-10-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 試料を傷めない量子もつれ電子顕微鏡の開発2013

    • Author(s)
      金澤理花、宮澤輔、岡本洋
    • Organizer
      細胞を創る研究会6.0
    • Place of Presentation
      鶴岡市先端研究産業支援センター
    • Related Report
      2013 Research-status Report
  • [Remarks] A Qubit Design Based on... (字数制限により以下略)

    • URL

      https://arxiv.org/abs/1608.02363

    • Related Report
      2016 Annual Research Report
  • [Remarks] okamoto-san@akita

    • URL

      https://sites.google.com/site/okamotohiroshisan/

    • Related Report
      2014 Research-status Report
  • [Remarks] okamoto-san@akita, "Research"

    • URL

      https://sites.google.com/site/okamotohiroshisan/home/okamotohiroshisan-2

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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