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Regulation of biomembrane structure by protein binding

Research Project

Project/Area Number 25400425
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological physics/Chemical physics/Soft matter physics
Research InstitutionThe University of Tokyo

Principal Investigator

Noguchi Hiroshi  東京大学, 物性研究所, 准教授 (00514564)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords生物物理 / ソフトマター / 細胞 / 生体膜 / シミュレーション
Outline of Final Research Achievements

We have studied shape transitions of biomembranes using coarse-grained simulations. (i) We have revealed the condition where membrane-fluctuation-induced attraction between ligand-receptor sites binding neighboring membranes induces assembly of the binding cites. (ii) We have clarified that the polymer anchoring reduces the line tension of membrane edges, as well as the interfacial line tension between membrane domains. We have found that instead of the mixing of two phases as observed in typical binary fluids, densely anchored polymers stabilize small domains. (iii) We have revealed that banana-shaped protein rods assemble via two continuous directional phase separations unlike a conventional two-dimensional phase separation. For high protein density, polygonal tube and polyhedral vesicles are formed. (iv) We found that high-genus vesicles can exhibit a discrete transition from a polyhedral stomatocyte to a discocyte.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (20 results)

All 2016 2015 2014 2013

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 3 results) Presentation (12 results) (of which Int'l Joint Research: 2 results,  Invited: 7 results)

  • [Journal Article] Formation of polyhedral vesicles and polygonal membrane tubes induced by banana-shaped proteins2015

    • Author(s)
      H. Noguchi
    • Journal Title

      J. Chem. Phys.

      Volume: 143 Issue: 24

    • DOI

      10.1063/1.4931896

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Shape transitions of high-genus fluid vesicles2015

    • Author(s)
      H. Noguchi
    • Journal Title

      EPL

      Volume: 112 Issue: 5 Pages: 58004-58004

    • DOI

      10.1209/0295-5075/112/58004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Two- or three-step assembly of banana-shaped proteins coupled with shape transformation of lipid membranes2014

    • Author(s)
      H. Noguchi
    • Journal Title

      EPL

      Volume: 108 Issue: 4 Pages: 48001-48001

    • DOI

      10.1209/0295-5075/108/48001

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 粒子描像の流体力学計算手法 II2014

    • Author(s)
      野口博司
    • Journal Title

      分子シミュレーション研究会会誌 “アンサンブル”

      Volume: 16 Pages: 59-65

    • NAID

      130005075261

    • Related Report
      2014 Research-status Report
  • [Journal Article] 粒子描像の流体力学計算手法 III2014

    • Author(s)
      野口博司
    • Journal Title

      分子シミュレーション研究会会誌 “アンサンブル”

      Volume: 16 Pages: 211-214

    • NAID

      130005093454

    • Related Report
      2014 Research-status Report
  • [Journal Article] 粒子描像の流体力学計算手法 IV2014

    • Author(s)
      野口博司
    • Journal Title

      分子シミュレーション研究会会誌 “アンサンブル”

      Volume: 16 Pages: 252-254

    • NAID

      130005107030

    • Related Report
      2014 Research-status Report
  • [Journal Article] Entropy-driven aggregation in multilamellar membranes2013

    • Author(s)
      H. Noguchi
    • Journal Title

      EPL

      Volume: 102 Issue: 6 Pages: 68001-68001

    • DOI

      10.1209/0295-5075/102/68001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanical properties and microdomain separation of fluid membranes with anchored polymers2013

    • Author(s)
      H. Wu, H. Shiba, and H. Noguchi
    • Journal Title

      Soft Matter

      Volume: 9 Issue: 41 Pages: 9907-9907

    • DOI

      10.1039/c3sm51680f

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 高いトポロジー種数を持つ脂質ベシクルの形態転移2016

    • Author(s)
      野口博司
    • Organizer
      第71回日本物理学会年次大会
    • Place of Presentation
      東北学院大学(宮城県仙台市)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] タンパク質吸着による生体膜の形態変化2015

    • Author(s)
      野口博司
    • Organizer
      第5回ソフトマター研究会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Shape transition of biomembrane induced by banana-shaped proteins2015

    • Author(s)
      H. Noguchi
    • Organizer
      The 3rd International Workshops on Advances in Computational Mechanics
    • Place of Presentation
      KFC Hall (東京都墨田区)
    • Year and Date
      2015-10-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Membrane tubulation induced by banana-shaped proteins2015

    • Author(s)
      H. Noguchi
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Self-Assembly of Banana-Shaped Proteins2015

    • Author(s)
      H. Noguchi
    • Organizer
      Physics of Structural and Dynamical Hierarchy in Soft Matter
    • Place of Presentation
      東京大学生産技術研究所(東京都目黒区)
    • Year and Date
      2015-03-16 – 2015-03-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 生体膜の変形によるBARドメインの凝集機構2014

    • Author(s)
      野口博司
    • Organizer
      日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Flow-induced morphological changes of bilayer membranes2014

    • Author(s)
      Hiroshi Noguchi, Hayato Shiba, and Gerhard Gompper
    • Organizer
      Workshop on Cross Correlation & Transport Phenomena in Soft Matter
    • Place of Presentation
      東京都新宿区
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Entropy-driven aggregation in multilamellar membranes2013

    • Author(s)
      Hiroshi Noguchi
    • Organizer
      International Soft Matter Conference 2013
    • Place of Presentation
      Rome, Italy
    • Related Report
      2013 Research-status Report
  • [Presentation] 生体膜の構造形成:空間拘束と高分子修飾2013

    • Author(s)
      野口博司
    • Organizer
      物性研短気研究会「エネルギーと新材料の物性・物質科学」
    • Place of Presentation
      千葉県柏市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 生体膜の形成する形態の多様性2013

    • Author(s)
      野口博司
    • Organizer
      HPCI戦略プログラム分野1×分野2 シンポジウム 「生体分子複合システムを計算する」~相互作用は何をもたらすのか」
    • Place of Presentation
      愛知県名古屋市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 界面活性剤集合体の構造形成のシミュレーション2013

    • Author(s)
      野口博司
    • Organizer
      Workshop: CROSSroads of Users and J-PARC 第10回「生体膜•コロイド研究の最前線」
    • Place of Presentation
      茨城県東海村
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] エントロピー駆動による膜間結合サイトの凝集体形成2013

    • Author(s)
      野口博司
    • Organizer
      国際高等研研究プロジェクト「分子基盤に基づく生体機能ネットワークとダイナミクスの解明」第2回研究会
    • Place of Presentation
      京都府木津川市
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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