| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
A wide range of screening of vapochromic organic crystals, a series of quinolone and new-quinolone antibiotic drugs were found to show vapochromic feature. Pipemidic acid trihydrate crystal showed dehydration phase transition by acetonitrile vapor, and back to be hydrate by humidity application. During this transition, the crystal color turned from colorless to yellow as the result of vapochromism. The crystal structure of the pipemidic acid anhydrous phase was determined at the first time by utilizing the Structure Determination from Powder diffraction Data technique which was recently developed. From the comparison of the crystal structures between before and after dehydration, molecular position rearrangement in the crystal induced an intra-molecular proton-transfer which affected the energy level of the molecular orbitals.
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