| Project/Area Number |
25410023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical chemistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
Saigusa Hiroyuki 横浜市立大学, 生命ナノシステム科学研究科, 教授 (90162180)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKAMOTO Masaki 名古屋大学, 情報科学研究科, 助教 (10362295)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 核酸塩基 / 水和クラスター / 中赤外レーザー / 尿酸 / ローカルモード結合 / 中赤外レーザー分光 / レーザー脱離 / CO伸縮振動 / ペプチド / 水和構造 / 赤外スペクトル / ヌクレオチド / 塩基対生成 |
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| Outline of Final Research Achievements |
In order to model the hydration structure of nucleic acid systems in relation to their biological functions, we have performed structural characterization of corresponding hydrated clusters isolated in the gas-phase. We have been able to establish an effective strategic method for elucidating hydration structure of nucleotides, in which a sugar-phosphate group is bonded to the base.
With this financial support, we have also developed a novel Mid-IR spectroscopic system and measured CO stretching vibrational spectra of uric acid and its monohydrates.It was found that the two structural isomers of the monohydrated cluster show very different local mode-coupling behavior, depending strongly upon the hydrogen-bonding site. By using this mode coupling scheme, we have been able to identify unambiguously the hydrogen-bonded structure of uric acid-melamine complex.
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