| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
The conventional synthetic method needs dangerous fluorine gas as a fluorine source. Therefore, a safe and convenient fluorination process is desirable.
On the basis of the previous results on hypervalent iodine chemistry, this study is aimed at developing a safe and convenient fluorination reaction without dangerous fluorine gas.
(1) A safe and convenient synthetic method of fluorinated dicarbonyl compounds has been developed by a simple procedure using commercially available hydrofluoric acid and iodosylbenzene. (2) Fluorination of ketones has been developed using HF reagents/PhIO. This method is useful as a convenient fluorination reaction because there are no reports for direct fluorination of ketones. (3) Catalytic fluorination of carbonyl compounds has been developed using iodobenzene catalyst. Since this catalytic fluorination does not need transition metal catalysts, metal-free, epoch-making catalytic fluorination is achieved.
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