| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Optically active pyrrolidine derivatives are biologically active compounds and pharmaceutically important. Asymmetric 1,3-dipolar cycloaddition and conjugate addition of glycine iminoesters (azomethine ylide precursors) with active alkenes are effective for divers oriented synthesis of amino acid derivatives. Silver acetate/ThioClickFerrophos complex activates effectively azomethine ylide and catalyzes asymmetric 1,3-dipolar cycloaddition and conjugate addition reaction with active alkenes to afford optically active products with high stereoselection. The methodology can lead to diverse oriented synthesis of optically active amino acids and drug discovery.
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