Development of catalytic transformations that include multiple bond cleavages and formations
| Project/Area Number |
25410054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ロジウム / パラジウム / 金 / 環化 / 炭素－炭素結合切断 / 複素環式化合物 / 多置換ベンゼン / 触媒 / 酸化 / 結合切断 / 結合生成 / 芳香族化合物 / 有機合成 / メタセシス / 合成 / シクロプロペノン / 金触媒 / スピロ環化 / 炭素ー炭素結合切断 / ヒドラジン / ロジウム触媒 / インドール / 炭素－水素結合活性化 |
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| Outline of Final Research Achievements |
In this study, research on catalytic transformations involving multiple bond cleavages and formations was conducted, and more than ten reactions were developed. Spirobiindanones, arylideneindanes, and dihydrophenanthrenes were synthesized by rhodium-catalyzed arylation. Ring-opening coupling reactions of cyclopropenones afforded alkenyl alkynyl ketones and spirocyclic cyclopentanones. Hydrazine derivatives underwent rhodium-catalyzed cyclization reactions to give indoles and phthalazinones. Maleic anhydrides coupled with alkynes and diynes to afford pyrones and benzenes, respectively. Rhodium-catalyzed reaction of pyridylmethylenecyclobutanes gave indanes through a skeletal rearrangement. On the other hand, pyridylmethylenecyclobutenes underwent rhodium-catalyzed intermolecular coupling with alkynes to afford multisubstituted benzenes.
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Report
(4 results)
Research Products
(42 results)
