| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Model studies of CO dehydrogenase (CODH) and acetyl CoA synthase (ACS) were conducted to elucidate the unrevealed mechanism of the carbon fixation process of acetyl CoA pathway in nature. As a CODH active site model, a novel [4Fe-5S-Ni] cluster was synthesized by utilizing our unique tridentate thiolate ligands. For our model studies of ACS, a series of dinuclear nickel complexes having tetra-anionic diamido-dithiolate ligand “mbea” modeling the plausible intermediates included in the ACS catalytic pathway was synthesized, and the thioester formation reaction modeling the ACS was accomplished. The results considerably contribute to elucidate the ACS reaction mechanism, and provide clues to the development of new carbon fixation reactions.
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