Development of novel molecular probes toward bio-imaging and photopharmacology of neural systems
| Project/Area Number |
25410082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional solid state chemistry
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| Research Institution | Utsunomiya University |
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Principal Investigator |
OBA Toru 宇都宮大学, 工学(系)研究科(研究院), 教授 (30291793)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAI Junichi 埼玉大学, 脳抹消科学研究センター, 教授 (80237198)
OHKURA Masamichi 埼玉大学, 脳抹消科学研究センター, 准教授 (70369172)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 蛍光プローブ / 膜電位 / 神経細胞 / 超分子 / 電子移動 / 環境応答性 / ケミカルバイオロジー / 励起エネルギー移動 / 光異性化 |
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| Outline of Final Research Achievements |
This study aims at development of novel molecular probes for researches of neural systems. (1) We successfully developed novel voltage sensitive fluorescent probes. (2) We developed selective iodination of the vinyl group and meso-position of a chlorophyll derivative and a natural porphyrin. We also developed facile, green conversion reactions of vinyl group into epoxy, formyl, and acetyl groups via the iodination. (3) We established design principles of pyridyl-pyrrole-based fluorescent probes. (4) We successfully developed novel environment-responsive fluorescent probes.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Ene-thiol reaction of C3-vinylated chlorophyll derivatives in the presence of oxygen: synthesis of C3- formyl-chlorins under mild conditions2013
Author(s)
T. Fukusumi, N. Takei, Y. Tateno, T. Aoki, A. Ando, K. Kozakai, H. Shima, T. Mizoguchi, S. Ito, T. Ikeda, H. Tamiaki, T. Oba
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Journal Title
J. Porphyrins Phthalocyanines
Volume: 17
Issue: 12
Pages: 1188-1195
DOI
Related Report
Peer Reviewed
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