Development of pH-activatable photosensitizers for photodynamic therapy
| Project/Area Number |
25410083
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional solid state chemistry
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Okutsu Tetsuo 群馬大学, 大学院理工学府, 教授 (20261860)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 光線力学療法 / 光増感剤 / 一重項酸素 / pH応答性 / ポルフィリン / pH / ON/OFFスイッチング / ON/OFF制御 |
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| Outline of Final Research Achievements |
We have developed the photosensitizers for photodynamic therapy. pH-activatable function has been introduced to tetraphenylporphyrin derivative by using aniline units to suppress photo-induced side effects of photodynamic therapy.
The photosensitization efficiency of the porphyrin with aniline unit was very low in the in the neutral condition (OFF state), but the photosensitization efficiency was recovered in the acidic condition (ON state). Furthermore, the pH-response could be optimized by changing the number of aniline units. A sharp pH-response and high ON/OFF switching ratio were obtained.
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Report
(4 results)
Research Products
(36 results)
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[Presentation] 光増感剤への活性制御機構の導入2014
Author(s)
堀内宏明・栗原亮太・狩野貴行・奥津哲夫
Organizer
第24回日本光線力学学会学術講演会
Place of Presentation
静岡県浜松市
Year and Date
2014-06-28 – 2014-06-29
Related Report
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