| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We have examined methods for efficiently generating silver(I) methoxide as well as methods for preparing silver(I) enolates from the methoxide. As a result, we have found that the Hunig base is effective as an additive for the purpose and desired silver(I) methoxide and the corresponding silver(I) enolates can be prepared with high purities. When an optically active phosphine compound has been used as an asymmetric ligand for silver(I) methoxide and a Mannich-type reaction via a chiral silver(I) enolate catalyzed by the chiral silver(I) methoxide has been performed, a high level of asymmetric induction has been observed for the Mannich product. Asymmetric α-amination and asymmetric aldol reaction have been also attained by applying the present catalytic method of generating chiral silver(I) enolates to various electrophiles. Further studies of diverse asymmetric reactions utilizing this catalytic system are underway.
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