| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Picolinic acid (pyridine-2-carboxylic acid) is a well known as chelating ligand and more than ten-thousands related complexes has been reported. On the other hand, the number of the reports concerning about extension for catalytic reactions is less, especially in asymmetric reactions. In this work, to present a potential of the picolinic acid for the transition-metal catalysis, we have aimed to construct the library of the chiral ligands, and investigated about optical stability through comparison with the stabilities of their corresponding benzoic acid derivatives. We have established catalytic asymmetric dehydrative intramolecular allylation of carboxylic acids to give alkenyl lactones, which is difficult to be realized by convensional Tsuji-Trost allylation.
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