| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Asymmetric synthesis of chiral organic molecules is a highly useful synthetic method for the preparation of various functional molecules. In particular, development of flexible methods for the preparation of compounds with a chiral quaternary stereogenic center is strongly required in medicinal chemistry. Previously, we succeeded in the enantioselective chlorination of b-keto esters with newly developed chiral Lewis acid catalyst. Here, we found that the SN2 reactions of resulting chlorides afforded the corresponding substituted products without loss of enantiopurity with water or phenol as the nucleophile. Furthermore, we demonstrated that the resulting substituted products could be converted into potential candidates of anti-diabetic drug.
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