| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
2-Aryl-4-quinolone synthesis was developed using the thermal rearrangement of iminocyclobutenones formed by a conjugate addition reaction of ketene silyl acetals to alkynyl imines. The 1,4- and 1,2-double nucleophilic addition reactions of ketene silyl acetals and trimethylsilyl cyanide to dialkynyl imines proceeded to give multi-substituted δ-lactam derivatives. Moreover, 1,4- and 1,6-double nucleophilic addition reactions of ketene silyl acetals to dialkynyl imines proceeded to give alkenyl iminocyclobutenones in good to high yields. Synthesis of a (±)-muscopyridine analogue was accomplished via the bicyclo-2-pyridone as a key intermediate, which was synthesized using ring-expansion reaction of the cyclic β-keto methyl ester with the alkynyl imine.
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