Development of environmental load-reducing oxidation reactions involving anti-Markovnikov nucleophilic attack to alkenes as a key step
| Project/Area Number |
25410116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nara Women's University |
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Principal Investigator |
Ura Yasuyuki 奈良女子大学, 自然科学系, 准教授 (40335196)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 環境低負荷型酸化反応 / アルケン / 逆マルコフニコフ求核攻撃 / アルデヒド合成 / パラジウム触媒 / 分子状酸素 / 末端アセタール合成 / 酸化的開裂 / 環境低負荷型反応 / パラジウム錯体触媒 / ビニルアレーン / 逆マルコフニコフ選択性 / アセタール合成 / パラジウム / Wacker型酸化反応 / アリールアセトアルデヒド / 末端アセタール / ベンズアルデヒド誘導体 / 逆マルコフニコフ型求核攻撃 |
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| Outline of Final Research Achievements |
We have developed three types of oxidation reactions, i.e., (1) synthesis of arylacetaldehydes via anti-Markovnikov Wacker-type oxidation, (2) synthesis of terminal acetals, (3) synthesis of benzaldehydes via oxidative cleavage of carbon-carbon double bond, using palladium catalysts and vinylarenes as substrates. These reactions proceeded under 1 atm of molecular oxygen (as a terminal oxidant) and mild reaction conditions, and thus these can be regarded as novel environmental load-reducing synthesis of aldehydes and their derivatives from terminal alkenes. The use of cyclic electron-deficient alkenes such as maleimide as additives was the key of the present reactions to enhance the catalytic activity.
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Report
(4 results)
Research Products
(17 results)
