Convergent Synthesis of Biologically Active Natural Products via Segment Coupling Involving Ether Ring Formation
Project/Area Number |
25410118
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Synthetic chemistry
|
Research Institution | Okayama University |
Principal Investigator |
KADOTA Isao 岡山大学, 自然科学研究科, 教授 (30250666)
|
Co-Investigator(Renkei-kenkyūsha) |
TAKAMURA Hiroyoshi 岡山大学, 大学院自然科学研究科, 助教 (70422798)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 全合成 / 海洋産天然物 / ポリ環状エーテル / 分子内アリル化 / 閉環メタセシス / シガトキシン / ダクチロライド / エニグマゾール / タムラミド |
Outline of Final Research Achievements |
Secondary metabolites produced by marine organism have been recognized as novel read compounds for new drag due to their potent bioactivities. However, because of the limited availability from nature, chemical synthesis has been required to obtain sufficient amounts of these compounds. Moreover, the unusual structures are particularly attractive targets for synthetic chemists. In this study, synthesis of these marine natural products was investigated by using convergent synthetic methodology based on intramolecular allylation.
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Report
(4 results)
Research Products
(42 results)
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[Presentation] Unified Total Synthesis and Biological Activity of Sarcophytonolides2015
Author(s)
H. Takamura, K. Iwamoto, E. Nakao, N. Harada, T. Kikuchi, O. Ohno, K. Suenaga, N. Endo, Y. Fukuda, and I. Kadota
Organizer
PACIFICHEM 2015
Place of Presentation
Honolulu, Hawaii
Year and Date
2015-12-19
Related Report
Int'l Joint Research
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[Presentation] スカブロライドFの合成研究2015
Author(s)
勝部友哉,森下諒平,髙村浩由,門田功
Organizer
2015年日本化学会中国四国支部大会
Place of Presentation
岡山大学津島キャンパス、岡山
Year and Date
2015-11-15
Related Report
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