| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Various transition metal catalysts have been used for organic synthesis. However, a new catalyst is still desired to improve the selectivity and enhance the catalytic activity. Iridium catalyst attracts much attention, because iridium catalyze the useful transformations not achieved by other transition metal catalysts. The aim of this project is to develop atom- and step-economical organic synthesis catalyzed by iridium complex. We studied the reaction scope and reaction mechanism of the following reactions. (1) [2+2+2] cycloaddition of diynes with alkynyl ketones and alkynyl esters. (2) [2+2+2] cycloaddition of diynes with cynamides. (3) [2+2+2] cycloaddition of diynes with acyl cyanides. (4) intermolecular hydroalkylation of simple alkenes with 1,3-diketones and alpha-ketoesters. (5) [2+2+2] cycloaddition of biaryl-linked diynes and heterobiaryl-linked diynes.
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