Development of a novel indium reducing catalytic system leading to a chemoselective reduction of carboxylic acids
| Project/Area Number |
25410120
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
SAKAI NORIO 東京理科大学, 理工学部, 准教授 (00328569)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | インジウム / ヒドロシラン / 化学選択性 / 還元 / 官能基変換 / 還元反応 / カルボン酸 / 単体硫黄 / チオエーテル / ガリウム / ハロゲン化アルキル / チオール |
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| Outline of Final Research Achievements |
It was found that when carboxylic acids were treated with indium bromide and 1,1,3,3-tetremethyldisiloxane (TMDS) in the presence of either halogen sources or mercaptans, the corresponding alkyl iodides, alkyl bromides and sulfides were obtained through a single-step transformation. Also, the combination of indium iodide and TMDS chemoselectively and directly reduced secondary amides to produce the corresponding secondary amines. Moreover, the combination of either In(OTf)3-TMDS or InI3-Et3SiH successively reduced nitrobenzenes to produce the corresponding azobenzenes and anilines, respectively.
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Report
(4 results)
Research Products
(73 results)
