| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We have studied synthetic strategy of block copolymers consisting glycopolymer as a hydrophilic segment to develop drug deliver system for immune cells such as macrophages and dendritic cells. We designed two types of block copolymers. One contains poly(lactic acid) as a hydrophobic segments for hydrophobic drug delivery, and the other has poly(L-lysine) as a cationic segments for nucleic acid delivery. We found that coupling method and bifunctional initiator method are promising strategies for synthesis of amphiphilic and cationic block glyco-copolymers, respectively. It should be noted that glycopolymer segments must have stability against acid hydrolysis for use in cationic block copolymer having poly(L-lysine). In addition, we demonstrate an enhanced cellular uptake of glycopolymer presenting mannose by RAW264.7 cells, showing targeting ability of glycopolymers.
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