Dual Stimuli-Responsive Self-Assemblies from Elastin-Synthetic Hybrid Graft-Copolymers
| Project/Area Number |
25410132
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | ペプチド・ポリマーハイブリッド / 多重応答ポリマー / エラスチン類似ペプチド / フォールディング / グラフトポリマー / 下限臨界溶液温度 / 構造色 / 温度応答性 / ポリイオン / 交互積層法 / 多重応答性ポリマー |
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| Outline of Final Research Achievements |
The main purpose of this research is to fabricate a novel molecular system, in which artificial polymers are conjugated with bio-related peptides as graft chains. An elastin-like peptide (ELP), which is known to take thermo-responsive conformational transition, has been employed as a peptide and attached to the pH-responsive poly(acrylic acid) and poly(allylamine) as graft chains. These conjugates have successfully shown LCST (lower critical solution temperature) behaviors responsive to dual stimuli of pH and temperature. The alternate layer-by-layer assembly prepared from such anionic and cationic conjugates has shown a reversible structural color variation based on thermo-induced polarity change of ELP chains.
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Report
(4 results)
Research Products
(20 results)
