| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The near-infrared (NIR) region (650-900 nm) is referred to as the “optical window” of cells and tissues because of the lack of efficient endogenous absorbers in this spectral range and the subsequent high penetration depth (of the order of a few millimeters) in most tissues. Organic fluorescent dyes that emit NIR fluorescence are preferable for applications in biological systems because they can reduce auto-fluorescence and photodamage to living cells. Therefore, we synthesized some new NIR fluorescent dyes for fluorescent imaging probes. For example, the absorption maxima of 2-Hydroxytryptanthrin under a pH range from 1.3 to 7.2 and from 8.5 to 10.6 were ca. 410 nm and ca. 495 nm, respectively. Moreover, the fluorescence maxima were ca. 660 nm regardless of the pH range. Its sodium salt (sodium tryptanthrin-2-olate) was water soluble and the fluorescence maxima were ca. 660 nm in both aprotic and protic solvents.
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