| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
In order to develop subdermally implantable devices for continuous blood glucose monitoring, we fabricated optical glucose sensing films with the semi-interpenetrating polymer network (semi-IPN) structure composed of glucose receptor-attached polymers and receptor specific dye-attached polymers, in which the receptor/dye complexes act as crosslinking points. The glucose sensing principle is based on the competitive binding of the receptor between the dye and glucose, providing a swelling of the sensing film due to the decrease in the number of crosslinking points in the polymer network: the swelling facilitates further dissociation of the receptor/dye complexes, leading to amplification of sensor color responses. The thus prepared sensing films showed remarkable absorbance responses for glucose (around 20% absorbance change in physiological glucose level) with reversible polymer swelling and shrinking.
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