Development of Sugar Sensing Nanoparticles with Signal Amplification Based on Swelling of hydrogel
| Project/Area Number |
25410141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | University of Toyama |
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Principal Investigator |
TOHDA Koji 富山大学, 大学院理工学研究部(工学), 教授 (60212065)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | オプティカルセンサー / 血糖値 / グルコースレセプター / ビスベンゾボロキソール / 高分子架橋点 / ポリマー膨潤 / フェニルボロン酸 / 競争的錯形成反応 |
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| Outline of Final Research Achievements |
In order to develop subdermally implantable devices for continuous blood glucose monitoring, we fabricated optical glucose sensing films with the semi-interpenetrating polymer network (semi-IPN) structure composed of glucose receptor-attached polymers and receptor specific dye-attached polymers, in which the receptor/dye complexes act as crosslinking points. The glucose sensing principle is based on the competitive binding of the receptor between the dye and glucose, providing a swelling of the sensing film due to the decrease in the number of crosslinking points in the polymer network: the swelling facilitates further dissociation of the receptor/dye complexes, leading to amplification of sensor color responses. The thus prepared sensing films showed remarkable absorbance responses for glucose (around 20% absorbance change in physiological glucose level) with reversible polymer swelling and shrinking.
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Report
(4 results)
Research Products
(17 results)
