• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of new analysis protocols for identification and imaging of molecules in tissues

Research Project

Project/Area Number 25410143
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Analytical chemistry
Research InstitutionSeikei University (2014-2016)
Shimane University (2013)

Principal Investigator

AOYAGI SATOKA  成蹊大学, 理工学部, 教授 (20339683)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords質量イメージング / 表面科学 / TOF-SIMS / 多変量解析 / 近接場赤外顕微鏡 / ToF-SIMS / データ解析 / イメージング / 国際情報交換 イギリス / 国際情報交換 ドイツ
Outline of Final Research Achievements

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is a powerful analysis method because it provides detailed chemical images with high spatial resolution approximately 100 nm. However, it is often difficult to interpret TOF-SIMS data, especially for the analysis of unknown materials in multicomponent samples, due to complex spectrum information. New analysis protocols for identification and imaging of molecules in complex samples using TOF-SIMS and near-field infrared microscopy, which also provides chemical mapping, have been developed.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (20 results)

All 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (4 results) Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 3 results,  Invited: 5 results) Remarks (1 results)

  • [Int'l Joint Research] Michael Durr/Justus-Liebig-Universitet Giessen(Germany)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Ian S. Gilmore/National Physical Laboratory(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] ギーセン大学(ドイツ)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] 物理学研究所(英国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Multivariate Analysis Applied to Polymer Imaging Data Obtained by Near-Field Infrared Microscopy2017

    • Author(s)
      Takayuki Yamagishi, Kenta Honobe, Satoka Aoyagi, Mayumi Okawa, Tomoko Kawashima
    • Journal Title

      e-Journal of Surface Science and Nanotechnology

      Volume: 15 Issue: 0 Pages: 19-24

    • DOI

      10.1380/ejssnt.2017.19

    • NAID

      130005464360

    • ISSN
      1348-0391
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ToF-SIMS analysis of amyloid beta aggregation on different lipid membranes2016

    • Author(s)
      Yuta Yokoyama, Satoka Aoyagi, Toshinori Shimanouchi, Miki Iwamura, Hideo Iwai
    • Journal Title

      Biointerphases

      Volume: 11 Issue: 2

    • DOI

      10.1116/1.4940706

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extraction of hidden information of ToF-SIMS data using different multivariate analysis2015

    • Author(s)
      Yuta Yokoyama, Tomoko Kawashima, Mayumi Ohkawa, Hideo Iwai and Satoka Aoyagi
    • Journal Title

      Surface and Interface Analysis

      Volume: 47 Issue: 4 Pages: 439-446

    • DOI

      10.1002/sia.5731

    • NAID

      130005143918

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] ToF-SIMS observation for evaluating the interaction between amyloid β and lipid membranes2015

    • Author(s)
      Satoka Aoyagi, Toshinori Shimanouchi, Tomoko Kawashima, Hideo Iwai
    • Journal Title

      Anal. Bioanal.Chem

      Volume: 407 Issue: 10 Pages: 2859-2863

    • DOI

      10.1007/s00216-015-8527-3

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ToF-SIMS data analysis for complex plant tissue samples using multivariate analysis and G-SIMS2014

    • Author(s)
      Satoka Aoyagi, Noriko Kodani, Akira Yano, Toshiki Asao, Hideo Iwai and Masahiro Kudo
    • Journal Title

      Surface and Interface Analysis

      Volume: 46 Issue: S1 Pages: 131-135

    • DOI

      10.1002/sia.5588

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of hydroxyapatite nanoparticles synthesized with phosphate surfactant by means of G-SIMS and g-ogram2014

    • Author(s)
      Yasuko Kajiwara, Hideo Iwai, Keizo Nakagawa, Noriko Kodani and Satoka Aoyagi
    • Journal Title

      Surface and Interface Analysis

      Volume: 46 Issue: S1 Pages: 209-212

    • DOI

      10.1002/sia.5398

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 飛行時間型二次イオン質量分析と近接場赤外顕微鏡による高分子および生体分子分布評価2016

    • Author(s)
      青柳里果、阿部聖、保延健太
    • Organizer
      第 36 回表面科学学術講演会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-11-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] Blood Adsorption onto Hollow Fibre Membrane2016

    • Author(s)
      Satoka Aoyagi
    • Organizer
      実用表面分析国際会議(PSA16)
    • Place of Presentation
      太田(デジョン)、韓国
    • Year and Date
      2016-10-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of Biomolecules Using Time-of-Flight Secondary Ion Mass Spectrometry2016

    • Author(s)
      Satoka Aoyagi
    • Organizer
      the 20th International Vacuum Congress (IVC-20)
    • Place of Presentation
      釜山、韓国
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Evaluation of Biomolecules Using Time-of-Flight Secondary Ion Mass Spectrometry2016

    • Author(s)
      Satoka Aoyagi
    • Organizer
      20th International Vacuum Congress (IVC-20)
    • Place of Presentation
      Busan
    • Year and Date
      2016-08-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 化学イメージング ~飛行時間型二次イオン質量分析(ToF-SIMS)イメージング と近接場赤外顕微鏡~2016

    • Author(s)
      青柳里果
    • Organizer
      第77回応用物理学会秋季学術講演会
    • Place of Presentation
      新潟
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Evaluation of the interaction between amyloid beta and lipid membranes using ToF-SIMS2014

    • Author(s)
      Satoka Aoyagi and Toshinori Shimanouchi
    • Organizer
      SIMS Europe 2014
    • Place of Presentation
      ミュンスター、ドイツ
    • Year and Date
      2014-09-07 – 2014-09-08
    • Related Report
      2014 Research-status Report
  • [Presentation] ToF-SIMS data analysis for complex samples using multivariate analysis and G-SIMS2013

    • Author(s)
      Satoka Aoyagi and Masahiro Kudo
    • Organizer
      the 19th International Conference on Secondary Ion Mass Spectrometry – (SIMS 19)
    • Place of Presentation
      済州島、韓国
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Evaluation of nanomaterials using time-of-flight secondary ion mass spectrometry (ToF-SIMS)2013

    • Author(s)
      Satoka Aoyagi
    • Organizer
      EMN Open Access Meeting
    • Place of Presentation
      成都、中国
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] A study of peptide fragmentation by Ar cluster ions of varying size and energy2013

    • Author(s)
      Satoka Aoyagi, Tomoko Kawashima, Melissa Passarelli, Rasmus Havelund, Ian S. Gilmore and Masahiro Kudo
    • Organizer
      9th International Symposium on Atomic Level Characterizations for New Materials and Devices ’13 (ALC13)
    • Place of Presentation
      ハワイ、米国
    • Related Report
      2013 Research-status Report
  • [Remarks] 物質計測・イメージング研究室

    • URL

      http://www.ml.seikei.ac.jp/spectra/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2022-02-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi