One-pot fabrication of ligand-decorated gold nanoparticles using peptide and high-sensitive colorimetric detection of toxic metal ions
| Project/Area Number |
25410161
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Japan Atomic Energy Agency |
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Principal Investigator |
SHIMOJO Kojiro 国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門 原子力基礎工学研究センター, 研究副主幹 (50414587)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 金ナノ粒子 / ペプチド / 配位子 / 有害金属 / 比色センサー |
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| Outline of Final Research Achievements |
This study focuses on the development of facile fabrication of gold nanoparticles (AuNPs) that can enable selective and high-sensitive colorimetric detection of toxic mercury Hg(II) ions. We prepared a peptide-substituted ligand (DGAA-A3) consisting of gold-binding peptide (A3) fused to diglycolamic acid framework (DGAA) with selectivity for Hg(II) ions. We have developed a simple one-pot strategy to fabricate DGAA-decorated AuNPs using the DGAA-A3 that can simultaneously direct both the synthesis of AuNPs and the immobilization of DGAA on the AuNPs in a single step. In addition, DGAA-decorated AuNPs can detect Hg(II) ions by simple color change from red to blue, based on cross-linkage of AuNPs by binding between Hg(II) ions and DGAA on the AuNPs.
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Report
(4 results)
Research Products
(19 results)
