| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Analysis of cardiac action potential is currently used to evaluate the pharmacological and toxicological properties of drugs. In this study, we developed a SECM system for analyzing contraction kinetics and energy metabolisms in cardiomyocytes. To analyze a glucose consumption in living cells, multiple enzymes were immobilized on a microelectrode surface by attachment at the termini of various double strands DNA. The enzyme immobilized microelectrode could be used for imaging glucose distributed in a local area.
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