Development of one step synthesis of glycosyl acceptor substituted by overcrowded silyl group and regioselective glycosidation at 3-OH
| Project/Area Number |
25410170
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bio-related chemistry
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| Research Institution | Saitama University |
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Principal Investigator |
HATANO Ken 埼玉大学, 理工学研究科, 准教授 (40332316)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | シリル基 / グリコシル化 / 位置選択的 / 糖鎖合成 / グリコシリ化 / シアリルラクトース / シアル酸 / 立体障害 / 速度論的反応 / 嵩高いケイ素置換基 / 糖水酸基 / 速度論的保護 / 位置選択的グリコシル化 / オリゴ糖合成 |
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| Outline of Final Research Achievements |
Silylation of hydroxyl groups on monosaccharides and lactose were obtained in good yield by one step reaction. In the case of lactose, the silylation occurred on 6, 2' and 6' positions of hydroxyl groups and the trisilylated lactose was able to isolate by recrystallization. Regioselective glycosydation at 3-OH (however 3'-OH in the case of lactose) of the silylated saccharides with a glucose derivative as a glycosyl donor were observed.
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Report
(4 results)
Research Products
(5 results)
