Development of the antimicrobial agent against H. pylori based on dual carbohydrate cluster effect
| Project/Area Number |
25410186
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Bio-related chemistry
|
|---|
| Research Institution | Josai University (2014-2015)
The Noguchi Institute (2013) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ODA YOSHIKI 公益財団法人野口研究所, 研究部, 研究員 (00442567)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | ピロリ菌 / 糖鎖クラスター / αGlcNAc / ルイスb糖鎖 / デンドリマー / シクロデキストリン / αＧｌｃＮＡｃ / ルイスb型糖鎖 / 抗ピロリ菌剤 / 糖鎖 / クラスター / Ｄｕａｌ糖クラスター / ルイスｂ糖鎖 |
|---|
| Outline of Final Research Achievements |
Helicobacter pylori lives in the surface mucous membrane of stomach, and binds to Lewis b sugar chain. The sugar chains containing the αGlcNAc residues show the growth inhibitory activity against H. pylori. Based on these two facts, this study achieves the synthesis of two types of αGlcNAc assemblies, and their antibacterial activities for H. pylori were clarified. In addition, this study accomplished the synthesis of the hybrid type sugars-assemblies composed of two kinds of sugars. Therefore, this study successfully leads to the development of the antibacterial agent for H. plylori involving the novel concept of “dual carbohydrate cluster effect”.
|
Report
(4 results)
Research Products
(18 results)
