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Development of the antimicrobial agent against H. pylori based on dual carbohydrate cluster effect

Research Project

Project/Area Number 25410186
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bio-related chemistry
Research InstitutionJosai University (2014-2015)
The Noguchi Institute (2013)

Principal Investigator

Yamanoi Takashi  城西大学, 薬学部, 教授 (20182595)

Co-Investigator(Kenkyū-buntansha) ODA YOSHIKI  公益財団法人野口研究所, 研究部, 研究員 (00442567)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsピロリ菌 / 糖鎖クラスター / αGlcNAc / ルイスb糖鎖 / デンドリマー / シクロデキストリン / αGlcNAc / ルイスb型糖鎖 / 抗ピロリ菌剤 / 糖鎖 / クラスター / Dual糖クラスター / ルイスb糖鎖
Outline of Final Research Achievements

Helicobacter pylori lives in the surface mucous membrane of stomach, and binds to Lewis b sugar chain. The sugar chains containing the αGlcNAc residues show the growth inhibitory activity against H. pylori. Based on these two facts, this study achieves the synthesis of two types of αGlcNAc assemblies, and their antibacterial activities for H. pylori were clarified. In addition, this study accomplished the synthesis of the hybrid type sugars-assemblies composed of two kinds of sugars. Therefore, this study successfully leads to the development of the antibacterial agent for H. plylori involving the novel concept of “dual carbohydrate cluster effect”.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2014 2013 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] Synthesis, structure, and evaluation of a β-cyclodextrin-artificial carbohydrate conjugate for use as a doxorubicin-carrying molecule2016

    • Author(s)
      T. Yamanoi, Y. Oda, K. Katsuraya, T. Inazu, K. Hattori
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 24 Issue: 4 Pages: 635-642

    • DOI

      10.1016/j.bmc.2015.12.030

    • NAID

      120006402349

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complete NMR assignment of a bisecting hybrid-type oligosaccharide transferred by Mucor hiemalis endo-β-N-acetylglucosaminidase2016

    • Author(s)
      T. Yamanoi, Y. Oda, K. Katsuraya, T. Inazu, K. Yamamoto
    • Journal Title

      Carbohydrate Research

      Volume: 427 Pages: 60-65

    • DOI

      10.1016/j.carres.2016.03.013

    • NAID

      120006483209

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stereoselectivity of D-psicofuranosylation influenced by protecting groups of psicofuranosyl donors2016

    • Author(s)
      T. Yamanoi, Y. Oda, T. Ishiyama, M. Watanabe
    • Journal Title

      Heterocycles

      Volume: 93 Issue: 1 Pages: 55-55

    • DOI

      10.3987/com-15-s(t)39

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 1)Formation of 2-Acetamido-2-deoxy-D-glucopyranosidic Linkages via Glycosidation Using a Combination of Two Lewis Acids2015

    • Author(s)
      Y. Oda, M. Midorikawa, T. Yamanoi
    • Journal Title

      Heterocycles

      Volume: 90 Issue: 1 Pages: 198-215

    • DOI

      10.3987/com-14-s(k)4

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 2)Stereocontrolled spirocyclization of exo-glucal derivatives for stereodivergent synthesis of spiro[5.5]ketals2014

    • Author(s)
      S. Matsuda, A. Yoshida, J. Nakagawa, M. Watanabe, Y. Oda, T. Yamanoi
    • Journal Title

      Tetrahedron Letters

      Volume: 55 Issue: 47 Pages: 6394-6398

    • DOI

      10.1016/j.tetlet.2014.09.095

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Formation of 1,2-cis-α-Aryl-glycosidic Linkages Directly from 2-Acetamido-2-deoxy-D-glucopyranosyl Acetate by the Mixed Activating System Using Ytterbium(III) Triflate and Catalytic Boron Trifluoride Diethyl Etherate Complex2014

    • Author(s)
      T. Yamanoi, M. Midorikawa, Y. Oda
    • Journal Title

      Heterocycles

      Volume: 88 Issue: 1 Pages: 201-206

    • DOI

      10.3987/com-13-s(s)44

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sugar-Sensitive Supramolecular Structures Based on Phenylboronic Acid-Modified Cyclodextrins2013

    • Author(s)
      K. Nakamura, T. Seki, Y. Egawa, R. Miki, Y. Oda, T. Yamanoi, T. Seki
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 61 Issue: 11 Pages: 1188-1191

    • DOI

      10.1248/cpb.c13-00542

    • NAID

      130003360911

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] D-フルクトピラノシル化反応の開発と利用2016

    • Author(s)
      石川順子、小泉晶彦、山ノ井孝
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] エストラジオールを用いたα-GlcNAc 誘導体の合成と、そのピロリ菌に対する増殖阻害活性作用2016

    • Author(s)
      蓮見悠介、小泉晶彦、中山淳、山ノ井孝
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] ドキソルビシン輸送キャリア分子としてのC-グルコシド結合型β-シクロデキストリン誘導体の合成、構造解析と評価2016

    • Author(s)
      山ノ井孝、小田慶喜、鬘谷要、服部憲治郎
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] αGlcNAc結合ステロイド誘導体の合成と、そのピロリ菌に対する増殖阻害活性作用2015

    • Author(s)
      山ノ井孝、小田慶喜、中山淳
    • Organizer
      第34回日本糖質学会
    • Place of Presentation
      東京大学
    • Year and Date
      2015-07-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] ベンジル化C-グルコピラノシド修飾β-シクロデキストリンのドキソルビシン包接特性とその構造2014

    • Author(s)
      山ノ井孝、小田慶喜、鬘谷 要、服部憲治郎
    • Organizer
      第31回シクロデキストリンシンポジウム
    • Place of Presentation
      島根県民会館
    • Year and Date
      2014-09-11 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] SSAレクチンのシアロ糖鎖に対する認識特異性の解明2014

    • Author(s)
      山ノ井孝、鬘谷 要、石村敬久、吉田 孝
    • Organizer
      第33回日本糖質学会年会
    • Place of Presentation
      名古屋大学豊田講堂
    • Year and Date
      2014-08-10 – 2014-08-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 糖質ハイブリッド集積型β-シクロデキストリンの合成研究2013

    • Author(s)
      中川純樹、小田慶喜、渡邊幹夫、山ノ井孝
    • Organizer
      第30回シクロデキストリンシンポジウム
    • Place of Presentation
      くまもと県民交流館パレア
    • Related Report
      2013 Research-status Report
  • [Presentation] DOSY法によるシクロデキストリン包接体の同定2013

    • Author(s)
      小田慶喜、鬘谷要、江川祐哉、関俊暢、山ノ井孝
    • Organizer
      第30回シクロデキストリンシンポジウム
    • Place of Presentation
      くまもと県民交流館パレア
    • Related Report
      2013 Research-status Report
  • [Presentation] 17-β-エストランジオール配糖体に対するγ-シクロデキストリンの包接作用2013

    • Author(s)
      鬘谷要・小田慶喜・山ノ井孝
    • Organizer
      第30回シクロデキストリンシンポジウム
    • Place of Presentation
      くまもと県民交流館パレア
    • Related Report
      2013 Research-status Report
  • [Presentation] Structural determination of multi-inclusion complexes composed of galactosylated estradiol and γ-cyclodextrin using DOSY and ROESY NMR methods2013

    • Author(s)
      Y. Oda, K. Katsuraya, T. Yamanoi
    • Organizer
      7th Asian Cyclodextrin Conference
    • Place of Presentation
      Chulalongkorn University(バンコク)(タイ)
    • Related Report
      2013 Research-status Report
  • [Remarks] 研究室紹介_有機薬化学研究室

    • URL

      http://www.josai.ac.jp/education/pharmacy/medicine_dep/laboratory/yukiyakukagaku.html

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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